{"id":"W7108628094","doi":"10.1182/blood-2025-3102","title":"An updated systematic review and meta-analysis of caplacizumab for immune thromboticthrombocytopenic purpura: Insights into efficacy and safety","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Observational study; Adverse effect; Placebo; Randomized controlled trial; Meta-analysis; Confidence interval; Clinical trial; Relative risk","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000400278,0.0002381411,0.002938956,0.0002510986,0.0001772976,0.00001952046,0.0002745735,0.00009902248,0.0003703815],"category_scores_gemma":[0.0001404879,0.0001722047,0.0003903825,0.0004588401,0.0001413082,0.00009279044,0.0001254755,0.00006963495,0.000005909775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001628854,"about_ca_system_score_gemma":0.00004569049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007411754,"about_ca_topic_score_gemma":0.00009475009,"domain_scores_codex":[0.9978531,0.0005353577,0.0009849883,0.0003999198,0.0000407892,0.0001858543],"domain_scores_gemma":[0.9983773,0.0003569055,0.0003498177,0.0007448756,0.0001445645,0.00002656038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001461513,0.001446647,0.0002612992,0.1229972,0.8117633,0.000002427135,0.0006698473,0.000005276007,0.05466018,0.007525377,0.0005063784,0.00001593242],"study_design_scores_gemma":[0.002921597,0.0001905424,0.00344397,0.0009507573,0.9854578,0.000007689328,0.0001664734,0.000008152411,0.006409998,0.0001212956,0.0001202099,0.000201507],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2822226,0.7116612,0.0002765669,0.0003167313,0.0000701009,0.005045677,0.0002304951,0.00006665944,0.0001099671],"genre_scores_gemma":[0.997561,0.001171946,0.00009362231,0.0001440834,0.000001686577,0.0002462323,0.0005431532,0.0000106888,0.0002275689],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7153385,"threshold_uncertainty_score":0.7022303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305558357144763,"score_gpt":0.3026509015855126,"score_spread":0.279595318014065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}