{"id":"W7109978277","doi":"10.3390/jdad2040046","title":"Functional Connectome Alterations Across the Spectrum of Alzheimer’s Disease","year":2025,"lang":"en","type":"article","venue":"Journal of dementia and Alzheimer's disease","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Pfizer; Novartis Pharmaceuticals Corporation; F. Hoffmann-La Roche; Biogen; Eli Lilly and Company; Servier; GE Healthcare; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association; Merck","keywords":"Disease; Temporal lobe; Connectome; Default mode network; Hippocampus; Cognition; Perirhinal cortex; Functional connectivity; Human Connectome Project","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003730509,0.0003579594,0.0003822139,0.001383336,0.0001485273,0.0004669742,0.0002926571,0.0003734608,0.0006289587],"category_scores_gemma":[0.0009253113,0.0001157408,0.0003856297,0.0009535304,0.000271522,0.0005525053,0.0002513379,0.0003161224,0.0001057538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00040583,"about_ca_system_score_gemma":0.0003220494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001921993,"about_ca_topic_score_gemma":0.003178493,"domain_scores_codex":[0.9999133,0.00001819089,0.000009890571,0.00003275397,0.00001811409,0.000007735883],"domain_scores_gemma":[0.9998291,0.00009321278,0.00003894041,0.000006725704,0.0000245819,0.000007496857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004353322,0.00007594916,0.03712067,0.01599433,0.001547968,0.0018484,0.001077419,0.007200351,0.04182437,0.01450566,0.007189235,0.8711803],"study_design_scores_gemma":[0.00006736591,0.001137588,0.6302304,0.009576755,0.004711472,0.02434155,0.001292875,0.01426539,0.02988666,0.07727006,0.2069149,0.0003051113],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1668901,0.8037744,0.01617062,0.001657578,0.0002264091,0.00008970804,0.001683633,0.0001518474,0.009355742],"genre_scores_gemma":[0.4196911,0.5694198,0.007788201,0.0004134001,0.0002163584,0.0001084239,0.001027247,0.0000196807,0.00131595],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001921993,"threshold_uncertainty_score":0.003821671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03901095251183773,"score_gpt":0.30070619761619,"score_spread":0.2616952451043523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}