{"id":"W7110017582","doi":"10.3390/curroncol32120690","title":"The Role of Homologous Recombination Deficiency (HRD) in Renal Cell Carcinoma (RCC): Biology, Biomarkers, and Therapeutic Opportunities","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Renal cell carcinoma; Homologous recombination; Disease; Tyrosine kinase; Clinical significance; Immune checkpoint; DNA repair; Mechanism (biology); Immune system; Clear cell renal cell carcinoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00108662,0.0003683043,0.0007592468,0.001950855,0.0002234377,0.001236997,0.0004000421,0.0007589061,0.0012402],"category_scores_gemma":[0.002797253,0.0001488616,0.0005605748,0.001988477,0.0006043628,0.001139258,0.0005205327,0.0008863275,0.0002846238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005377749,"about_ca_system_score_gemma":0.001396543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087337,"about_ca_topic_score_gemma":0.001346147,"domain_scores_codex":[0.9994609,0.000152526,0.0001305813,0.00009855639,0.0001295771,0.00002777857],"domain_scores_gemma":[0.9984282,0.00101396,0.0003193072,0.00003063375,0.000171353,0.00003651497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002161878,0.0000350668,0.005315197,0.04445865,0.0003972568,0.0007558154,0.0003392452,0.0003933364,0.002002976,0.007572678,0.01670677,0.9218068],"study_design_scores_gemma":[0.00003087257,0.0003601207,0.01458557,0.0341184,0.001758686,0.01159077,0.0007202919,0.0003570517,0.002264939,0.007496322,0.9266338,0.00008326117],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005055071,0.9978834,0.0001912477,0.0008652137,0.00009693867,0.000003982042,0.00005465483,0.000003482665,0.0003955599],"genre_scores_gemma":[0.00896069,0.9894744,0.0003837021,0.0005300816,0.0003455291,0.00001001214,0.00009964399,0.000001990827,0.0001939463],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001950855,"threshold_uncertainty_score":0.005746663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08420431400621371,"score_gpt":0.3837505146493781,"score_spread":0.2995462006431645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}