{"id":"W7110798330","doi":"10.1021/acsbiomedchemau.5c00224","title":"Is Thiourea the Weak Link? An Investigation of the In Vitro and In Vivo Destabilization of [ 203 Pb]- and [ 212 Pb]Pb 2+ Thiourea-Based Bioconjugates","year":2025,"lang":"en","type":"article","venue":"ACS Bio & Med Chem Au","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta; Simon Fraser University","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Mitacs; Canada Foundation for Innovation","keywords":"Bioconjugation; Biodistribution; In vivo; Thiourea; In vitro; Chelation; Linker; Amide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001506152,0.0004433016,0.0008313314,0.000363704,0.0001897879,0.00006398303,0.0004039328,0.0003574588,0.0000610915],"category_scores_gemma":[0.00100384,0.0002734142,0.0001220119,0.0009781668,0.0008373396,0.000236708,0.0001763964,0.0004496443,0.000002161709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184588,"about_ca_system_score_gemma":0.0004581109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008794478,"about_ca_topic_score_gemma":0.0002460209,"domain_scores_codex":[0.9968907,0.0005441786,0.0009909229,0.0005965928,0.000523722,0.0004538975],"domain_scores_gemma":[0.9976819,0.0006910117,0.0003208324,0.0008982377,0.000250479,0.0001575652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006469639,0.0001862271,0.08282969,0.000927129,0.0001013174,0.000001918537,0.01552273,0.0007999283,0.8955078,0.0003104887,0.0003152514,0.002850613],"study_design_scores_gemma":[0.001719376,0.0002229792,0.00913064,0.0008199686,0.0002214511,0.000007320416,0.003861666,0.02321422,0.9583086,0.001542294,0.0007047106,0.0002468273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882454,0.001430668,0.00007031692,0.008449036,0.00003756561,0.001155282,0.00005615451,0.00004063319,0.0005149962],"genre_scores_gemma":[0.9968737,0.0002423332,0.0009056597,0.001410249,0.00009051574,0.00008509471,0.00005943635,0.00004447655,0.0002885858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07369905,"threshold_uncertainty_score":0.9999718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661627860238922,"score_gpt":0.2543478153462283,"score_spread":0.2277315367438391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}