{"id":"W7110798330","doi":"10.1021/acsbiomedchemau.5c00224","title":"Is Thiourea the Weak Link? An Investigation of the In Vitro and In Vivo Destabilization of [ 203 Pb]- and [ 212 Pb]Pb 2+ Thiourea-Based Bioconjugates","year":2025,"lang":"en","type":"article","venue":"ACS Bio & Med Chem Au","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta; Simon Fraser University","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Mitacs; Canada Foundation for Innovation","keywords":"Bioconjugation; Biodistribution; In vivo; Thiourea; In vitro; Chelation; Linker; Amide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001750849,0.000178714,0.0001110012,0.00006698478,0.00009086449,0.0001630942,0.0001311377,0.0001965461,0.0005535012],"category_scores_gemma":[0.0002499591,0.00008781354,0.0001047452,0.00006772167,0.0001926012,0.0001772961,0.00009221522,0.0002074894,0.00008578204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410654,"about_ca_system_score_gemma":0.00009628165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004046263,"about_ca_topic_score_gemma":0.000474358,"domain_scores_codex":[0.9999335,0.00001760658,0.000003625767,0.00001323095,0.00002103804,0.00001113609],"domain_scores_gemma":[0.9998785,0.00003132831,0.00004741057,0.000008736298,0.00002114758,0.00001280378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008271868,0.000006592415,0.0001706747,0.00003248387,0.00000593535,0.00003426239,0.00001885471,0.00006394224,0.9977437,0.00009006824,0.00001684571,0.00173399],"study_design_scores_gemma":[0.000002632822,0.0002691649,0.001163672,0.00000392842,0.00001373382,0.00007924528,0.00001277924,0.0004100361,0.9970252,0.00002554116,0.0009917538,0.00000234135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935091,0.002840484,0.002655119,0.00006216135,0.00001334715,0.00001304741,0.00003485679,0.00002784743,0.0008438473],"genre_scores_gemma":[0.9968262,0.001049968,0.001138391,0.00005368101,0.000006605746,0.00001174597,0.00004723596,0.000009743972,0.0008565616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005535012,"threshold_uncertainty_score":0.001851618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661627860238922,"score_gpt":0.2543478153462283,"score_spread":0.2277315367438391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}