{"id":"W7110962056","doi":"10.1021/acs.molpharmaceut.4c01173.s001","title":"PharmaceuticalNitrosamines: A Comprehensive Reviewof Health Risks, Detection, Mitigation Strategies Supplemented withCYP450 Interactions as Molecular Simulations for Mechanistic Insightinto Carcinogenicity","year":2025,"lang":"","type":"article","venue":"Figshare","topic":"Water Treatment and Disinfection","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Nitrosamine; Carcinogen; Cytochrome P450; Human health; Drug; Pharmaceutical drug","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005957283,0.001577595,0.001426577,0.0009689512,0.0003776692,0.0008020034,0.0008286881,0.00106915,0.003907601],"category_scores_gemma":[0.0006490314,0.0005690823,0.001804487,0.001194083,0.0002720711,0.001243232,0.0006396231,0.001127591,0.001090363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005905061,"about_ca_system_score_gemma":0.0009031662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002637371,"about_ca_topic_score_gemma":0.003340825,"domain_scores_codex":[0.9997317,0.00006978372,0.00002718551,0.00004195159,0.0001011875,0.00002820348],"domain_scores_gemma":[0.9997476,0.0001330206,0.0000448326,0.00001424177,0.00004825816,0.00001211751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002642742,0.0004655279,0.001674609,0.0700326,0.001063515,0.0007228827,0.0002883562,0.08731209,0.03328785,0.04079242,0.04060294,0.7234929],"study_design_scores_gemma":[0.00007187516,0.001000144,0.001982284,0.006151762,0.001144535,0.0009989463,0.0001546582,0.0422055,0.01937679,0.01574569,0.9109926,0.0001753109],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004446432,0.9796322,0.009892254,0.0008013807,0.0002539952,0.00005320542,0.0003047254,0.0001370937,0.004478666],"genre_scores_gemma":[0.01597096,0.9761968,0.005109892,0.0003143286,0.0002006141,0.000067688,0.000313946,0.0000310146,0.001794703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003907601,"threshold_uncertainty_score":0.01307219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0738841553429046,"score_gpt":0.3954173727506981,"score_spread":0.3215332174077935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}