{"id":"W7111493484","doi":"","title":"INTERLINK-1: Phase III study of cetuximab (CTX) ± monalizumab (M) in participants (pts) with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) with disease progression on/after platinum chemotherapy (CT) and previously treated with an immune checkpoint inhibitor (ICI)","year":2023,"lang":"en","type":"article","venue":"Research Explorer (The University of Manchester)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Interim analysis; Cetuximab; Head and neck cancer; Hazard ratio; Clinical endpoint; Head and neck squamous-cell carcinoma; Placebo; Confidence interval; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001316341,0.001459517,0.001396587,0.0003789826,0.0003933783,0.0008604935,0.00111844,0.001367696,0.007851787],"category_scores_gemma":[0.000713623,0.0006933034,0.0009537539,0.0002583101,0.0006776674,0.0008310288,0.000567108,0.002648068,0.001373519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000941185,"about_ca_system_score_gemma":0.001506839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001238742,"about_ca_topic_score_gemma":0.004464661,"domain_scores_codex":[0.9996576,0.0001771637,0.00001280134,0.00005826659,0.00003251177,0.00006162083],"domain_scores_gemma":[0.999569,0.00005845789,0.00009456095,0.00002507681,0.00002319562,0.000229622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8816852,0.04972265,0.001987391,0.0007765327,0.0007294015,0.00006605828,0.0001501201,0.001122371,0.02072205,0.0001969869,0.003050676,0.03979047],"study_design_scores_gemma":[0.7431996,0.2477621,0.003880845,0.00002886801,0.0003533921,0.00006515179,0.00002886473,0.0005482733,0.00199454,0.0001182816,0.002003469,0.0000166223],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.984306,0.002245028,0.0006373355,0.0004930041,0.0001970803,0.006004379,0.001913344,0.0002361195,0.003967738],"genre_scores_gemma":[0.9776149,0.001907634,0.001990978,0.0009246796,0.0002217215,0.006564763,0.002670511,0.00005324463,0.008051408],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.007851787,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06625848813984087,"score_gpt":0.3306015236822024,"score_spread":0.2643430355423615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}