{"id":"W7111794773","doi":"","title":"Knockout of adenylosuccinate synthase purA increases susceptibility to colistin in Escherichia coli","year":2024,"lang":"en","type":"article","venue":"Okayama University Scientific Achievement Repository (Okayama University)","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ryobi Teien Memory Foundation; Japan Society for the Promotion of Science; Keio University","keywords":"Colistin; Mutant; Purine metabolism; Escherichia coli; Stringent response; Bacterial outer membrane; ATP synthase; Nucleotidase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396784,0.0006259531,0.000492915,0.0004749471,0.0001472828,0.000480367,0.0003221124,0.0006052823,0.001498957],"category_scores_gemma":[0.0003209898,0.000361158,0.0003593582,0.0003425946,0.0003403848,0.0002355276,0.0004344578,0.0006895721,0.0004358698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003505363,"about_ca_system_score_gemma":0.0002082807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007115317,"about_ca_topic_score_gemma":0.0006579477,"domain_scores_codex":[0.9996666,0.00005397725,0.00005701481,0.00006653018,0.00009096694,0.00006503942],"domain_scores_gemma":[0.999503,0.0001071715,0.0001541169,0.00004827655,0.00003808221,0.0001493237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006238951,0.00003016939,0.0001378635,0.00001721148,0.000003702756,0.00006853238,0.00001062255,0.00003175018,0.9992558,0.0000260846,0.00001703412,0.0003387388],"study_design_scores_gemma":[0.00001853771,0.0003406265,0.01040145,0.00001658057,0.00002092729,0.0004876126,0.00007419723,0.001168752,0.9863381,0.00005108686,0.001067095,0.00001497279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962384,0.0004666523,0.001617488,0.0001146904,0.00002700102,0.00003041149,0.0006250054,0.0001198451,0.0007606572],"genre_scores_gemma":[0.9940308,0.0004685745,0.002288239,0.00008018276,0.000007694165,0.00004079237,0.0006937208,0.00006868312,0.002321223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498957,"threshold_uncertainty_score":0.005014539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00744875686667684,"score_gpt":0.2087836400653058,"score_spread":0.201334883198629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}