{"id":"W7112232143","doi":"","title":"CSF total tau as a proxy of synaptic degeneration","year":2025,"lang":"en","type":"other","venue":"Lume (Universidade Federal do Rio Grande do Sul)","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Fonds de Recherche du Québec - Santé; National Institutes of Health; Instituto Serrapilheira; UK Dementia Research Institute; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; HORIZON EUROPE Framework Programme; Alzheimer's Society; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Global Brain Health Institute; EU Joint Programme – Neurodegenerative Disease Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Neurodegeneration; Neurogranin; Cerebrospinal fluid; Biomarker; Degeneration (medical); Atrophy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007084936,0.0005519286,0.0003171291,0.002368734,0.0003627842,0.0009170959,0.0003350785,0.0002765516,0.004721113],"category_scores_gemma":[0.001788577,0.0001151475,0.0002135733,0.001575816,0.0002716636,0.0002149277,0.000495805,0.0002359726,0.001292847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005160708,"about_ca_system_score_gemma":0.000509938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01321551,"about_ca_topic_score_gemma":0.02340093,"domain_scores_codex":[0.9995987,0.00008601257,0.0000467615,0.00008982057,0.0001395334,0.00003925696],"domain_scores_gemma":[0.9989032,0.0001499374,0.0003856504,0.0001117633,0.0003039379,0.0001455266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008533533,0.000184982,0.9341896,0.0002879167,0.0001889068,0.0009242956,0.0004349481,0.0001660306,0.00670492,0.0004898949,0.01013735,0.04543772],"study_design_scores_gemma":[0.00003833045,0.0001746759,0.9829334,0.0001335003,0.00009357647,0.00208094,0.0005163404,0.0008689843,0.00274374,0.0007607702,0.009638495,0.00001716218],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439495,0.002897942,0.0009673325,0.0005995174,0.0001149915,0.0001397602,0.01991664,0.0002309087,0.03118341],"genre_scores_gemma":[0.9866863,0.0007582177,0.001365499,0.0001610565,0.00004378903,0.00005620918,0.004423225,0.00004558343,0.006460096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01321551,"threshold_uncertainty_score":0.02627718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006172395047526364,"score_gpt":0.221641254923949,"score_spread":0.2154688598764226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}