{"id":"W7112330988","doi":"","title":"Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex","year":2024,"lang":"en","type":"article","venue":"JuSER (Forschungszentrum Jülich)","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Institut de Recherches Servier; National Health and Medical Research Council; Canadian Institutes of Health Research; Irving Medical Center, Columbia University; Avid Radiopharmaceuticals; Parkinsonfonden; EMD Serono; AstraZeneca; European Commission; Fondation pour la Recherche sur Alzheimer; Genentech; National Institutes of Health; Arizona Biomedical Research Commission; Knut och Alice Wallenbergs Stiftelse; IXICO; H. Lundbeck A/S; Skånes universitetssjukhus; Alzheimer's Disease Neuroimaging Initiative; Stichting Dioraphte; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Novo Nordisk; Servier; Vetenskapsrådet; University of Southern California; Eisai; Australian Government; Lunds Universitet; Alzheimerfonden; Government of Canada; ZonMw; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; Alzheimer Society; Alzheimer Nederland; Cerveau Technologies; Pfizer Canada; Fondation Brain Canada; GHR Foundation; Prothena; Alzheimer's Association; Arizona Department of Health Services; Merck KGaA; Northern California Institute for Research and Education; McGill University; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Meso Scale Diagnostics; Cure Alzheimer's Fund; Sanofi","keywords":"Genotype; Apolipoprotein E; Cognitive impairment; Disease; Cognition; Association (psychology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006286726,0.0004866899,0.000615655,0.0004927043,0.0001908854,0.0004401343,0.00008444593,0.0001025701,0.0001883119],"category_scores_gemma":[0.00004252529,0.0003424612,0.00005126238,0.0006237183,0.0005730135,0.000488829,0.0002197984,0.000617889,0.00003133653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001345208,"about_ca_system_score_gemma":0.0003827154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004565232,"about_ca_topic_score_gemma":0.0005814751,"domain_scores_codex":[0.9967073,0.0001714232,0.0003456497,0.0008924468,0.0008583128,0.001024913],"domain_scores_gemma":[0.9988377,0.000188824,0.00007623152,0.0002393701,0.000136954,0.0005209136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001158346,0.0004595129,0.9855706,0.000657838,0.0007707594,0.001324064,0.00357739,5.605258e-7,0.0005246706,0.0004126569,0.0002973847,0.005246234],"study_design_scores_gemma":[0.006818177,0.003868425,0.9779601,0.001279212,0.0006678579,0.0008381111,0.002763253,0.0001695863,0.001832882,0.0002498906,0.003056427,0.000496062],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918981,0.001240331,0.0002241858,0.001121473,0.00004368066,0.00195096,0.0001573949,0.0001618437,0.00320206],"genre_scores_gemma":[0.9947233,0.0005339539,0.0006782579,0.000607678,0.00008286911,0.0001910179,0.0002081819,0.00009080708,0.002883903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007610469,"threshold_uncertainty_score":0.9999027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072903212737889,"score_gpt":0.289326237517859,"score_spread":0.2785972053904801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}