{"id":"W7112703516","doi":"","title":"Disruption of the murine calpain small subunit gene, Capn4:calpain is essential for embryonic development but not for cell growth and division","year":2000,"lang":"en","type":"article","venue":"Discovery Research Portal (University of Dundee)","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Embryonic stem cell; Cell division; Embryogenesis; Cell growth; Embryo; Protein subunit; Mutant; Calpain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912631,0.0009665742,0.0003471847,0.0007681638,0.0003573377,0.0003734115,0.0006797272,0.0006598944,0.002686296],"category_scores_gemma":[0.0003168176,0.0004114449,0.0003417176,0.000291429,0.0006251363,0.00028905,0.0004286191,0.0006334631,0.000975639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008318115,"about_ca_system_score_gemma":0.0004348298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119668,"about_ca_topic_score_gemma":0.002290999,"domain_scores_codex":[0.9997672,0.00003476281,0.00002781739,0.00005436204,0.00007396431,0.00004181185],"domain_scores_gemma":[0.9996374,0.00006518599,0.0001314758,0.0000395677,0.00002943758,0.00009700373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001857554,0.00003656147,0.000199125,0.00004129313,0.000007667707,0.0002333537,0.00001055152,0.0001079728,0.9973913,0.0002073467,0.0001545683,0.001424549],"study_design_scores_gemma":[0.00008244136,0.0002370355,0.005721091,0.00001754426,0.00004017261,0.001208884,0.00003154631,0.001353849,0.9827263,0.0001396349,0.008431136,0.00001038036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847035,0.00155151,0.007234727,0.000319943,0.0001194128,0.000107762,0.002349092,0.0003365211,0.003277501],"genre_scores_gemma":[0.9605985,0.00128256,0.01330419,0.0001429424,0.00004422152,0.0001565843,0.004293823,0.0002020091,0.01997523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002686296,"threshold_uncertainty_score":0.008986533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105111182093241,"score_gpt":0.2535220504498472,"score_spread":0.2324709386289148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}