{"id":"W7113099575","doi":"","title":"Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease.","year":2025,"lang":"en","type":"article","venue":"DZNE Pub","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Avid Radiopharmaceuticals; National Institutes of Health; Fondation Brain Canada; Ministry of Science and ICT, South Korea; Japan Agency for Medical Research and Development; Eli Lilly and Company; Fleni; Genentech; Deutsches Zentrum für Neurodegenerative Erkrankungen; Canadian Institutes of Health Research; GHR Foundation; National Institute on Aging; Alzheimer's Association","keywords":"Astrocytosis; Immunohistochemistry; Monoclonal antibody; Cerebrospinal fluid; Neuropathology; Microfauna; White matter; Tauopathy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004631064,0.0001364332,0.0004238752,0.0002755925,0.00002300632,0.000005546428,0.0001009885,0.00007497111,0.0002542444],"category_scores_gemma":[0.0005938003,0.0001022821,0.0001389156,0.0004709567,0.0001329706,0.00005908541,0.00005470672,0.0001151526,0.000008983227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401226,"about_ca_system_score_gemma":0.001479781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001602796,"about_ca_topic_score_gemma":0.00001209582,"domain_scores_codex":[0.9982085,0.0001489057,0.0004653095,0.0002388278,0.0006933231,0.000245169],"domain_scores_gemma":[0.998911,0.0001025447,0.0001096319,0.0003894465,0.0003422625,0.0001451319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8531386,0.01298669,0.03812268,0.0005617235,0.01450962,0.0002909161,0.0003287481,0.00001225861,0.01059808,0.0003686745,0.00264356,0.06643845],"study_design_scores_gemma":[0.523388,0.002601189,0.4163542,0.00191273,0.01284916,0.00001435254,0.0003350567,0.006582372,0.03358845,0.001540197,0.0003879084,0.0004464034],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828374,0.01352241,0.000006281316,0.0003689667,0.00009182412,0.001698093,0.00005205351,0.00001441986,0.00140857],"genre_scores_gemma":[0.9992542,0.000113145,0.0000815598,0.00002941231,0.00002997395,0.0002315672,0.000179564,0.00001237038,0.00006826909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3782315,"threshold_uncertainty_score":0.4170944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06530151904841645,"score_gpt":0.3992985924407905,"score_spread":0.3339970733923741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}