{"id":"W7113146127","doi":"","title":"Updated overall survival (OS) data from the phase 1b study of tebentafusp (tebe) as monotherapy or combination therapy with durvalumab (durva) and/or tremelimumab (treme) in metastatic cutaneous melanoma (mCM).","year":2022,"lang":"en","type":"article","venue":"Research Explorer (The University of Manchester)","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Particle Physics","funders":"","keywords":"Tremelimumab; Durvalumab; Combination therapy; Overall survival; Immunotherapy; Melanoma; Ipilimumab; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002708436,0.0007621638,0.001280703,0.0006100903,0.0002304837,0.0008845583,0.0006429909,0.0005023101,0.005269911],"category_scores_gemma":[0.002709592,0.0002818491,0.001181604,0.001275157,0.0001493274,0.0008143313,0.0004625628,0.001397574,0.001279714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007521466,"about_ca_system_score_gemma":0.0006986594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002164945,"about_ca_topic_score_gemma":0.007454103,"domain_scores_codex":[0.999314,0.0002706365,0.00007397981,0.00007903127,0.0001735298,0.00008885809],"domain_scores_gemma":[0.9977755,0.0005644768,0.0008100418,0.0001956312,0.0003106415,0.0003436825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3134802,0.00203558,0.1217671,0.00895852,0.0151803,0.0003931172,0.0003076865,0.009660396,0.01738919,0.001031597,0.1718432,0.3379532],"study_design_scores_gemma":[0.05114234,0.02752835,0.6922986,0.001106759,0.01844596,0.001323498,0.0001780173,0.001969974,0.005704046,0.00180464,0.1983642,0.000133607],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5216537,0.07311579,0.00381872,0.002571326,0.0006412145,0.001153156,0.3741727,0.0004688603,0.02240456],"genre_scores_gemma":[0.5718259,0.01561512,0.002808042,0.002403126,0.0003320578,0.001881699,0.3977592,0.0001905839,0.00718432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005269911,"threshold_uncertainty_score":0.01762962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1473776595549559,"score_gpt":0.3392203909086587,"score_spread":0.1918427313537029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}