{"id":"W7113899212","doi":"10.1158/1557-3265.earlyonsetca25-a023","title":"Abstract A023: Cell-Free DNA: A Paradigm Shift in Cancer Diagnostics and Precision Medicine","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Precision medicine; Precision oncology; Digital polymerase chain reaction; Circulating tumor DNA; Cell-free fetal DNA; Personalized medicine; Cancer; Liquid biopsy; Minimal residual disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01262826,0.000830227,0.001274982,0.002005541,0.001315871,0.006111269,0.002015065,0.008061698,0.01058049],"category_scores_gemma":[0.01160457,0.0004954436,0.001181793,0.001643956,0.007182276,0.007482748,0.00368003,0.009758713,0.005871534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004000025,"about_ca_system_score_gemma":0.004661329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001629313,"about_ca_topic_score_gemma":0.00085025,"domain_scores_codex":[0.9938447,0.002212899,0.0003309424,0.00100626,0.00229885,0.0003062868],"domain_scores_gemma":[0.9830464,0.008212508,0.0006787367,0.0009967225,0.005773511,0.001292163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000473245,0.0001370543,0.0008943408,0.003075719,0.00008544071,0.0004889932,0.0006779345,0.001078111,0.01401665,0.3171422,0.1524124,0.5095179],"study_design_scores_gemma":[0.0000526686,0.0003604398,0.0005720992,0.001268621,0.00003955937,0.001044264,0.000272285,0.001420341,0.009226022,0.1159751,0.8696713,0.00009728594],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006298088,0.4732831,0.1023331,0.3164243,0.04561972,0.0002522219,0.0009099743,0.001205398,0.05367418],"genre_scores_gemma":[0.1286899,0.4877802,0.1102378,0.1439505,0.05873105,0.0007672779,0.001399987,0.0009339165,0.06750938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01262826,"threshold_uncertainty_score":0.0667854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0977671510184656,"score_gpt":0.4848771013295494,"score_spread":0.3871099503110838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}