{"id":"W7114490623","doi":"","title":"Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control","year":2024,"lang":"en","type":"article","venue":"Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Imperial Biomedical Research Centre; European Regional Development Fund; Medical Research Council; Walloon excellence in life sciences and biotechnology; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Fondation Brain Canada; European Commission; Institut Mérieux; Conseil Régional Hauts-de-France; Institució Catalana de Recerca i Estudis Avançats; Fonds De La Recherche Scientifique - FNRS; Institut National de la Santé et de la Recherche Médicale; Government of Canada; National Institute for Health and Care Research; Rosetrees Trust; Ontario Genomics; Université de Lille; Canada First Research Excellence Fund; Genome Canada; British Heart Foundation; CHIST-ERA; Australian Government; Agence Nationale de la Recherche; Wellcome Trust; Heart and Stroke Foundation of Canada","keywords":"Glycemic; Inflammation; Diabetes mellitus; Pathogenesis; Trimethylamine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017574,0.0003880826,0.0005392493,0.0002387185,0.0001573213,0.0003622784,0.0004632171,0.0004567752,0.01611247],"category_scores_gemma":[0.0002319623,0.0001987004,0.0003759244,0.0001372321,0.0002786413,0.0002735876,0.0004026004,0.001256785,0.002389427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002633721,"about_ca_system_score_gemma":0.0005082505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007214607,"about_ca_topic_score_gemma":0.001213401,"domain_scores_codex":[0.9998788,0.00002154855,0.000008031136,0.00002216271,0.00002109588,0.00004837214],"domain_scores_gemma":[0.9999118,0.000007636002,0.0000279998,0.00001387424,0.00000895988,0.00002977702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02902442,0.002508007,0.001054359,0.0005786631,0.0002519996,0.0002054978,0.00005488626,0.0004491037,0.8691251,0.000648489,0.008379547,0.08771995],"study_design_scores_gemma":[0.01219101,0.0368312,0.05249023,0.0003344293,0.0008498781,0.001305357,0.000532578,0.005043509,0.8058991,0.001893047,0.08250415,0.0001255052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696454,0.00959903,0.004184278,0.002331709,0.001780908,0.0001249172,0.001668484,0.001385866,0.009279499],"genre_scores_gemma":[0.9647914,0.004751652,0.004073149,0.0007708487,0.00021828,0.000162161,0.001306841,0.0001972748,0.02372836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01611247,"threshold_uncertainty_score":0.05390161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004303837572765591,"score_gpt":0.2046231593861811,"score_spread":0.2003193218134156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}