{"id":"W7114490623","doi":"","title":"Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control","year":2024,"lang":"en","type":"article","venue":"Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Imperial Biomedical Research Centre; European Regional Development Fund; Medical Research Council; Walloon excellence in life sciences and biotechnology; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Fondation Brain Canada; European Commission; Institut Mérieux; Conseil Régional Hauts-de-France; Institució Catalana de Recerca i Estudis Avançats; Fonds De La Recherche Scientifique - FNRS; Institut National de la Santé et de la Recherche Médicale; Government of Canada; National Institute for Health and Care Research; Rosetrees Trust; Ontario Genomics; Université de Lille; Canada First Research Excellence Fund; Genome Canada; British Heart Foundation; CHIST-ERA; Australian Government; Agence Nationale de la Recherche; Wellcome Trust; Heart and Stroke Foundation of Canada","keywords":"Glycemic; Inflammation; Diabetes mellitus; Pathogenesis; Trimethylamine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002598874,0.0004263391,0.0004418397,0.0003849581,0.0007002957,0.0001290733,0.0002143174,0.0003704802,0.000008205829],"category_scores_gemma":[0.00006432734,0.0004525692,0.0002637127,0.0003680689,0.0004599834,0.00007963402,0.0001473632,0.0003233792,0.000006299151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061473,"about_ca_system_score_gemma":0.000598011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002332665,"about_ca_topic_score_gemma":0.00001476424,"domain_scores_codex":[0.997413,0.0002309872,0.0007074641,0.0008718337,0.0003593413,0.0004174138],"domain_scores_gemma":[0.9987024,0.00007579783,0.0004063451,0.0003424358,0.0002661175,0.0002068909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005722179,0.0001632036,0.001681408,0.0002238858,0.0002342254,0.00009708971,0.0002427149,0.000221257,0.992662,0.0006137182,0.001336843,0.001951498],"study_design_scores_gemma":[0.002985654,0.0005243677,0.002975563,0.0004223389,0.0003581181,0.0003248754,0.0001821223,0.0005420703,0.8951899,0.00001138912,0.09593116,0.0005524151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990064,0.004184805,0.0012816,0.0001503339,0.0009412784,0.0003980553,0.0001281615,0.0001047547,0.002746982],"genre_scores_gemma":[0.9950595,0.0003039362,0.0004031268,0.00003533409,0.0006655339,0.000006157418,0.0004198554,0.0000330111,0.003073584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09747201,"threshold_uncertainty_score":0.9997926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004303837572765591,"score_gpt":0.2046231593861811,"score_spread":0.2003193218134156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}