{"id":"W7114914711","doi":"10.21203/rs.3.rs-8215051/v1","title":"PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Pennsylvania State University; University of Pennsylvania; Penn State College of Medicine; National Institutes of Health; Pennsylvania Department of Health","keywords":"Neuroinflammation; T cell; Downregulation and upregulation; Effector; Progressive multifocal leukoencephalopathy; Immune system; Programmed cell death; Blockade; Function (biology); Microglia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002091057,0.0003014104,0.0004861245,0.0008391557,0.0001966876,0.0001583606,0.0003888963,0.0004261659,0.00004575307],"category_scores_gemma":[0.002524728,0.0002108704,0.0001348304,0.0006403954,0.0001959118,0.00005684447,0.0004317695,0.001818589,0.00006861578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442425,"about_ca_system_score_gemma":0.000860665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004109872,"about_ca_topic_score_gemma":0.00004352168,"domain_scores_codex":[0.995487,0.001655191,0.0004617616,0.0006816185,0.001030756,0.000683675],"domain_scores_gemma":[0.9955626,0.002888208,0.0000925682,0.0008515301,0.0002908056,0.0003142989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04468999,0.004710482,0.1672886,0.027381,0.0006068981,0.006995598,0.01521017,0.004430182,0.4421651,0.001247349,0.2732078,0.01206678],"study_design_scores_gemma":[0.01814934,0.002692897,0.8738453,0.00954679,0.0003600371,0.00004901927,0.002605307,0.02529435,0.01666378,0.002606266,0.04690085,0.001286105],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642036,0.006483101,0.00001506255,0.02168623,0.0001212943,0.003322204,0.0006038576,0.00007860215,0.003486034],"genre_scores_gemma":[0.9916888,0.00115674,0.00003936458,0.000831153,0.0001849635,0.000300966,0.0002582393,0.00002876773,0.005511027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7065567,"threshold_uncertainty_score":0.8599047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0222107209788031,"score_gpt":0.3523209870751867,"score_spread":0.3301102660963836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}