{"id":"W7114917296","doi":"10.24433/co.1437646.v1","title":"ImmunoOncology Kinetics (IO-KIN); Peripheral BioMarkers of Response to ICB in HNSCC Patients","year":2025,"lang":"en","type":"other","venue":"Code Ocean","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Nivolumab; T-cell receptor; Peripheral; Peripheral blood; Clinical trial; Prospective cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007493529,0.0003190758,0.0005223458,0.0002035193,0.0002008932,0.0005955189,0.0002795647,0.0003214031,0.003194059],"category_scores_gemma":[0.0007889298,0.0001614275,0.0003194264,0.0002809434,0.0001927142,0.0004184669,0.0002567255,0.0006475754,0.0007796591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007115334,"about_ca_system_score_gemma":0.0004696057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009446375,"about_ca_topic_score_gemma":0.002682818,"domain_scores_codex":[0.9997599,0.00008794882,0.00001509757,0.00007104492,0.0000278258,0.00003824378],"domain_scores_gemma":[0.9994373,0.00009232542,0.0002016363,0.00005932694,0.0000620212,0.0001474343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3162215,0.005110555,0.3361341,0.001601898,0.00114217,0.0001341504,0.0001900314,0.003483047,0.02693374,0.0004683324,0.01303054,0.2955499],"study_design_scores_gemma":[0.05607329,0.1084096,0.7798213,0.0003875094,0.001718358,0.0007683996,0.0002556738,0.007928184,0.01266371,0.001380609,0.03046284,0.0001305529],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"software","genre_scores_codex":[0.9842498,0.003814758,0.000495431,0.0001976178,0.00006828343,0.0005795385,0.003923278,0.0001347976,0.00653656],"genre_scores_gemma":[0.9911674,0.0005929917,0.0009879152,0.0003654577,0.00004881011,0.0005345093,0.003672117,0.00003577828,0.002595014],"genre_candidate":"software","genre_consensus":null,"teacher_disagreement_score":0.003194059,"threshold_uncertainty_score":0.01068521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009076494831987619,"score_gpt":0.2739354686489245,"score_spread":0.2648589738169369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}