{"id":"W7114917296","doi":"10.24433/co.1437646.v1","title":"ImmunoOncology Kinetics (IO-KIN); Peripheral BioMarkers of Response to ICB in HNSCC Patients","year":2025,"lang":"en","type":"other","venue":"Code Ocean","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Nivolumab; T-cell receptor; Peripheral; Peripheral blood; Clinical trial; Prospective cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005578987,0.0005614561,0.0009441379,0.001955763,0.00002457576,0.0000209815,0.0008610693,0.0006985224,0.002098394],"category_scores_gemma":[0.000919173,0.0006201757,0.0001725624,0.001156965,0.0002620533,0.00002680692,0.0003915748,0.000336815,0.0007425501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008545316,"about_ca_system_score_gemma":0.0004468909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000433619,"about_ca_topic_score_gemma":0.00126075,"domain_scores_codex":[0.9966561,0.0008137281,0.0007529291,0.0007153981,0.0004288798,0.0006329787],"domain_scores_gemma":[0.9978818,0.0002141602,0.00047465,0.001104362,0.0001747675,0.0001502832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006724382,0.0006459785,0.01881639,0.0001439084,0.000253014,0.00004243387,0.0004485362,0.00002273953,0.004018586,0.00004178076,0.9675084,0.001333875],"study_design_scores_gemma":[0.003959957,0.0008050249,0.06139537,0.0008618768,0.00008666312,0.000001613029,0.00009941336,0.00002708804,0.0003499153,0.00003141089,0.9317067,0.0006750092],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.3004262,0.001318178,0.00005240391,0.0003604156,0.00263595,0.003214528,0.007107332,0.0005728855,0.6843121],"genre_scores_gemma":[0.208559,0.00005968321,0.002770736,0.0005046034,0.0001472796,0.00004201199,0.0006522469,0.002542682,0.7847218],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1004097,"threshold_uncertainty_score":0.999625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009076494831987619,"score_gpt":0.2739354686489245,"score_spread":0.2648589738169369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}