{"id":"W7115000040","doi":"10.64898/2025.12.12.693909","title":"Evaluation of peptidomimetic inhibitors","year":2025,"lang":"en","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium","keywords":"Peptidomimetic; Drug discovery; Surface plasmon resonance; Förster resonance energy transfer; Isothermal titration calorimetry; Fluorescence spectroscopy; Drug; Drug design","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005372823,0.0007625958,0.0005697949,0.0003967811,0.0001654914,0.0004823934,0.0002788898,0.0003881603,0.001941945],"category_scores_gemma":[0.0003697297,0.0001630626,0.0001817535,0.0003926432,0.0001664436,0.0003053594,0.0002087204,0.0006324433,0.0005135628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004213503,"about_ca_system_score_gemma":0.0002760771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004809482,"about_ca_topic_score_gemma":0.0008715325,"domain_scores_codex":[0.9995549,0.00008839971,0.000057184,0.00008105278,0.0001571588,0.0000612616],"domain_scores_gemma":[0.9998239,0.00003317437,0.00003423789,0.00001336166,0.00004501176,0.00005030604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004408707,0.000221881,0.0002573489,0.0001653812,0.000027116,0.00005686986,0.00001471574,0.0009442408,0.9881867,0.0001513448,0.0002760904,0.009257457],"study_design_scores_gemma":[0.0001228715,0.003354807,0.001274363,0.00001748089,0.00003761238,0.0002263934,0.00001413979,0.002544379,0.9880056,0.00004718833,0.004342873,0.00001231387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657089,0.01126476,0.009943138,0.000243701,0.0001986162,0.0006941856,0.003740289,0.0003124975,0.007894005],"genre_scores_gemma":[0.9783188,0.003773492,0.01014529,0.0001708009,0.00002678985,0.0002121235,0.002774453,0.00003616304,0.004542178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941945,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515809547449872,"score_gpt":0.2502918719152772,"score_spread":0.2351337764407785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}