{"id":"W7115165605","doi":"10.1016/j.jaccao.2025.09.004","title":"Pretreatment Circulating Vascular Biomarkers Predict Cancer Therapy–Related Cardiac Dysfunction During HER2+ Breast Cancer Treatment","year":2025,"lang":"en","type":"article","venue":"JACC CardioOncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Princess Margaret Cancer Centre; University Health Network; Toronto General Hospital; University of Toronto; Toronto Rehabilitation Institute; Ted Rogers Centre for Heart Research","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Canadian Cancer Society; Canada Foundation for Innovation; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Cancer; Breast cancer; Cardiac dysfunction; Biomarker; Disease; Cardiotoxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002538119,0.000425444,0.001030802,0.0002804827,0.0002766383,0.00002953155,0.00007827394,0.0004801983,0.0002385619],"category_scores_gemma":[0.00001829858,0.0003693043,0.0009230478,0.0006249325,0.0001159255,0.0001155625,0.00003612328,0.0002398902,0.000009547693],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00413202,"about_ca_system_score_gemma":0.0006787743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001812165,"about_ca_topic_score_gemma":0.00007221269,"domain_scores_codex":[0.997716,0.0002636585,0.0004378645,0.0007308481,0.0003273275,0.0005243127],"domain_scores_gemma":[0.9988365,0.00008421722,0.0001634917,0.0005520394,0.000199439,0.0001643114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001388921,0.000441268,0.2907603,0.0002191075,0.024867,0.0001257711,0.001158594,0.001925223,0.3853256,0.00004070443,0.0008749597,0.2928726],"study_design_scores_gemma":[0.01414343,0.0004912987,0.8390479,0.0003996215,0.002160136,0.0001971335,0.000533532,0.0003309251,0.1265777,0.00003246431,0.01564628,0.0004395665],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786237,0.008208718,0.00007354826,0.002037263,0.001960855,0.002009448,0.0001130423,0.0002753813,0.00669803],"genre_scores_gemma":[0.9870201,0.009058936,0.00005161894,0.0002571853,0.0006411762,0.001295469,0.00009621926,0.00005787548,0.001521466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5482876,"threshold_uncertainty_score":0.9998759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147338698459344,"score_gpt":0.2787020829196181,"score_spread":0.2672286959350247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}