{"id":"W7115273503","doi":"","title":"Polygenic prediction of body mass index and obesity through the life course and across ancestries","year":2024,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center of Innovation Program; Core Research for Evolutional Science and Technology; Institute of Genetics; UCB Pharma; Biosense Webster; National Cancer Institute; National Institute on Aging; National Key Research and Development Program of China; Health and Social Care Research and Development Division; Departament d'Universitats, Recerca i Societat de la Informació; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Sahlgrenska Akademin; Cancer Council Victoria; Canadian Institutes of Health Research; Elizabeth Blackwell Institute for Health Research, University of Bristol; Helsinki Institute of Life Science, Helsingin Yliopisto; Perelman School of Medicine, University of Pennsylvania; Centers for Disease Control and Prevention; Turun Yliopistosäätiö; Amsterdam Neuroscience; Sygehus Lillebælt; Diabetesforeningen; Heinz Nixdorf Stiftung; Freistaat Sachsen; Diabetestutkimussäätiö; Wageningen University and Research; H. Lundbeck A/S; Abbott Diagnostics; Provincia autonoma di Bolzano - Alto Adige; Hjartavernd; Takeda Pharmaceutical Company; Fondation du cancer du sein du Québec; Servier; Xarxa de Bancs de Tumors de Catalunya; University of Toronto; Syöpäsäätiö; Siemens Healthineers; Amgen; University of Kelaniya; European Commission; Tays; Case Western Reserve University; Landelijke Stichting voor Blinden en Slechtzienden; Deutsche Forschungsgemeinschaft; Taichung Veterans General Hospital; Deutsches Krebsforschungszentrum; Egmont Fonden; Chinese Society of Clinical Oncology; Consejo Nacional de Ciencia y Tecnología; Novo Nordisk Fonden; University of Bristol; Safe Work Australia; Wake Forest School of Medicine; Karl-Franzens-Universität Graz; Diabetesliitto; National Cancer Research Institute; Gratama Stichting; Instituto de Salud Carlos III; Otsuka Pharmaceutical; Novo Nordisk; Institut National Du Cancer; Wetenschappelijk Onderzoek- en Documentatiecentrum; Radboud Universitair Medisch Centrum; Oulun Yliopisto; Göteborgs Universitet; Lastentautien Tutkimussäätiö; National University Health System; Universität Hamburg; Medical Research Council; Dasman Diabetes Institute; Fundación IMSS; National and Kapodistrian University of Athens; Sydäntutkimussäätiö; Universitair Medisch Centrum Groningen; Oogfonds; Universitetet i Bergen; Umeå Universitet; Instituto Mexicano del Seguro Social; Canadian Cancer Society Research Institute; National Health Research Institutes; Deutsche Krebshilfe; Office of the First Minister and Deputy First Minister; Queen's University; Universität zu Lübeck; Faculty of Medicine and Health, University of Sydney; Oesterreichische Nationalbank; Juho Vainion Säätiö; Ludwig-Maximilians-Universität München; Emil Aaltosen Säätiö; National Research Foundation of Korea; Augustinus Fonden; Korea Institute of Science and Technology; Lundbeckfonden; Faculty of Health and Medical Sciences, University of Western Australia; Fondation Leducq; Lunds Universitet; Samfundet Folkhälsan; Hjerteforeningen; Ministero della Salute; Fundación Marqués de Valdecilla; Alexion Pharmaceuticals; Amsterdam University Medical Centers; Fonds Wetenschappelijk Onderzoek; Nierstichting; KfH-Stiftung Präventivmedizin; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Kela; Yrjö Jahnssonin Säätiö; Economic and Social Research Council; National Natural Science Foundation of China; Universitätsklinikum Regensburg; Danmarks Grundforskningsfond; Universiteit Leiden; Cotswold Foundation; Norges Forskningsråd; Science Foundation Ireland; United Kingdom Clinical Research Collaboration; Stockholms Läns Landsting; GlaxoSmithKline; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Children's Hospital of Philadelphia; Invitae; Murdoch University; Ministero dell’Istruzione, dell’Università e della Ricerca; March of Dimes Foundation; British Heart Foundation; Centre for Ageing Research and Development in Ireland; Genome Canada; Boston Scientific Corporation; Scottish Government; University of Cambridge; Council of Scientific and Industrial Research, India; Skånes universitetssjukhus; National Institutes of Health; National University of Singapore; Samsung; Prostate Cancer Foundation of Australia; Queen's University Belfast; Rosetrees Trust; Prostate Cancer Canada; University of Notre Dame Australia; Turun Yliopistollinen Keskussairaala; National Medical Research Council; Suomen Kulttuurirahasto; Government of Canada; Health~Holland; Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen; Janssen Scientific Affairs; JST-Mirai Program; National Institute of Biomedical Innovation; Public Health Agency; Eli Lilly and Company; Department for the Economy; Regione Campania; National Research Foundation Singapore; National Research Foundation; Else Kröner-Fresenius-Stiftung; Jan Dekker Stichting; Department of Health, Government of Western Australia; Austrian Science Fund; National Institute for Health and Care Research; Helmholtz Zentrum München; Helsingin Yliopisto; Folkhälsanin Tutkimussäätiö; National Center for Global Health and Medicine; Leidos; Cancer Research Institute; NorthShore University HealthSystem; Stichting Blindenhulp; Swedish Cancer Foundation; Korea National Institute of Health; Center for Translational Molecular Medicine; Karolinska Institutet; Vlaamse regering; Broad Institute; Australian Government; Foundation for Cardiovascular Research; Wellcome Trust; Regeneron Pharmaceuticals; Radboud Universiteit; Tampereen Tuberkuloosisäätiö; Pancreatic Cancer UK; Bundesministerium für Bildung und Forschung; Fondation Institut de Cardiologie de Montréal; University of Michigan; Government of the United Kingdom; Signe ja Ane Gyllenbergin Säätiö; Japan Agency for Medical Research and Development; Sungkyunkwan University; National Science Foundation; Institut de Cardiologie de Montréal; University of Thessaly; Gentofte Hospital; Movember Foundation; Bristol-Myers Squibb; Helse Sør-Øst RHF; Royal Marsden NHS Foundation Trust; Scottish Funding Council; Biomedical Research Council; Gilead Sciences; Ministry of Education, Culture, Sports, Science and Technology; Helsingin ja Uudenmaan Sairaanhoitopiiri; Rijksuniversiteit Groningen; Danone; University of Notre Dame; University of Pennsylvania; Medizinische Universität Graz; Bayer; Juvenile Diabetes Research Foundation International; Medical Research Council Canada; Deutsches Zentrum für Herz-Kreislaufforschung; Turun Yliopisto; Finska Läkaresällskapet; Yale University; Pfizer; Vrije Universiteit Amsterdam; Victor Chang Cardiac Research Institute; Deutsche Herzstiftung; Atlantic Philanthropies; Government of Western Australia; Women and Infants Research Foundation; Paavo Nurmen Säätiö; Ovarian Cancer Research Fund; China-Japan Friendship Hospital; TrygFonden; Leids Universitair Medisch Centrum; Prostate Cancer Foundation; Sanofi; Vincent Fairfax Family Foundation; National Science Council; Breast Cancer Research Foundation; Mitsubishi Tanabe Pharma Corporation; Agency for Science, Technology and Research; Knut och Alice Wallenbergs Stiftelse; Nederlandse Zuivel Organisatie; AstraZeneca; Dalhousie University; Stiftelsen för Strategisk Forskning; Foundation for the National Institutes of Health","keywords":"Body mass index; Obesity; Biobank; Life course approach; Longitudinal study; Anthropometry; Body weight; Young adult; Longitudinal data","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001563363,0.0005791633,0.0003055132,0.0008949008,0.0005001013,0.0007758064,0.0003377108,0.0004759049,0.002098049],"category_scores_gemma":[0.002723232,0.0002795716,0.001064857,0.001216409,0.0003384252,0.0004849914,0.0009557446,0.0009466358,0.000284794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003093522,"about_ca_system_score_gemma":0.0004153518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01464082,"about_ca_topic_score_gemma":0.02173033,"domain_scores_codex":[0.9991387,0.0003446906,0.00005153499,0.0002530641,0.00009969151,0.0001122927],"domain_scores_gemma":[0.9984398,0.0004749662,0.0004325704,0.0003146061,0.0001800064,0.0001580892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001097594,0.00004058093,0.983451,0.00002053968,0.0007051522,0.00008545876,0.00008971235,0.0008259402,0.000695523,0.0004310182,0.0004380492,0.01310734],"study_design_scores_gemma":[0.000003768473,0.00005246469,0.9968213,0.000009554932,0.0001411164,0.0001017244,0.00003676232,0.001550695,0.0001200063,0.00059269,0.0005637155,0.000006313461],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819742,0.001966953,0.009089704,0.0007959183,0.00005880143,0.00005965342,0.003009112,0.00008089771,0.002964776],"genre_scores_gemma":[0.9932314,0.0007646045,0.003067632,0.0001414444,0.00003061064,0.00004826572,0.001846217,0.00001555289,0.0008542573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01464082,"threshold_uncertainty_score":0.02911121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009837431950132399,"score_gpt":0.2374820828345302,"score_spread":0.2276446508843978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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