{"id":"W7115388119","doi":"","title":"Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder","year":2024,"lang":"en","type":"article","venue":"UCL Discovery (University College London)","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute on Aging; National Medical Research Council; National Health and Medical Research Council; Canadian Institutes of Health Research; National Institute on Alcohol Abuse and Alcoholism; Avid Radiopharmaceuticals; National Institute on Deafness and Other Communication Disorders; Allergan; European Commission; Genentech; Région Normandie; Agencia Nacional de Investigación y Desarrollo; National University Health System; Medical Research Council; Servier; Vancouver Coastal Health Research Institute; National Institutes of Health; Children's Hospital Foundation; Mitacs; Eisai; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Institut National de la Santé et de la Recherche Médicale; Department of Psychiatry, University of Toronto; Biogen; Agence Nationale de la Recherche; Signe ja Ane Gyllenbergin Säätiö; Indian Council of Medical Research; National Research Foundation; National Research Foundation Singapore; National Institute for Health and Care Research; Alzheimerfonden; Singapore Institute for Clinical Sciences; Michael Smith Health Research BC; Jane ja Aatos Erkon Säätiö; Association France Alzheimer; Fondation Vaincre Alzheimer; U.S. Department of Defense; Eli Lilly and Company; Canadian Network for Mood and Anxiety Treatments; University of Toronto; U.S. Department of Veterans Affairs; Government of the United Kingdom; National Science Foundation; Temple University; Wellcome Trust; Canada First Research Excellence Fund; Max-Planck-Gesellschaft; Bristol-Myers Squibb; Pfizer; Bill and Melinda Gates Foundation; National Alliance for Research on Schizophrenia and Depression; Fondation Brain Canada; Rosetrees Trust; H. Lundbeck A/S; Sunovion","keywords":"Major depressive disorder; Neurocognitive; Working memory; Depression (economics); Cohort; Cognition; Late life depression; Association (psychology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002961719,0.0002799141,0.0002236685,0.0004349795,0.0002838108,0.0004458952,0.0003295191,0.0004124353,0.001206972],"category_scores_gemma":[0.00167472,0.0001625068,0.0002092682,0.0004215968,0.0002284934,0.0001990895,0.0003487221,0.0004617117,0.0001257185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002785388,"about_ca_system_score_gemma":0.0001782643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004593641,"about_ca_topic_score_gemma":0.006428571,"domain_scores_codex":[0.9998976,0.00002888266,0.00001995234,0.00001903143,0.00001699139,0.00001750304],"domain_scores_gemma":[0.9989775,0.0001913123,0.0005078415,0.00007404975,0.0000937556,0.0001555729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001444521,0.0002222293,0.9882597,0.00003692511,0.0001671977,0.0006611171,0.0001570192,0.0001046462,0.002393024,0.00005760103,0.0002346835,0.006261413],"study_design_scores_gemma":[0.000005278266,0.000050069,0.9995373,0.000002515545,0.00001313598,0.0001848656,0.00004104448,0.0000438948,0.00004539559,0.00003373169,0.00004101568,0.000001699075],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989235,0.000446881,0.00002765618,0.00008119237,0.00001187883,0.000002849825,0.0001112791,0.000002449126,0.0003922748],"genre_scores_gemma":[0.9995058,0.0001431914,0.00005010243,0.00002491238,0.00001685832,0.000002987762,0.0001076471,0.000001191853,0.0001473299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004593641,"threshold_uncertainty_score":0.009133816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009964677750692836,"score_gpt":0.2072566381044682,"score_spread":0.1972919603537753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}