{"id":"W7115560268","doi":"10.1093/ckj/sfaf393","title":"Complement activation in anti-glomerular basement membrane disease before and after treatment with imlifidase","year":2025,"lang":"en","type":"article","venue":"Clinical Kidney Journal","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ingrid Asps Stiftelser; Region Skåne; Vetenskapsrådet","keywords":"Complement system; Autoantibody; Alternative complement pathway; Complement (music); Classical complement pathway; Disease; Basement membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009102091,0.0002593931,0.0006381807,0.0003928753,0.0002294045,0.0003885764,0.000210006,0.000486989,0.0008458893],"category_scores_gemma":[0.001257673,0.0001187233,0.0002856849,0.0003248927,0.000222867,0.0002710807,0.0001509554,0.0005871587,0.0001174889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004859871,"about_ca_system_score_gemma":0.000205099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000507165,"about_ca_topic_score_gemma":0.0004596331,"domain_scores_codex":[0.9995518,0.0001577665,0.0000381368,0.00008609855,0.00008581542,0.00008032826],"domain_scores_gemma":[0.9990959,0.0002703881,0.0002934272,0.00004696586,0.00008295703,0.0002102514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09465599,0.001585199,0.7883635,0.0003627526,0.0006039189,0.003335005,0.0004546148,0.0008565661,0.05301768,0.0001378226,0.00059841,0.05602862],"study_design_scores_gemma":[0.0009302397,0.0223817,0.9593946,0.00002959902,0.0003549322,0.003626222,0.0000777214,0.0007416751,0.01088937,0.0001074558,0.001440651,0.00002573899],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970515,0.002294255,0.0001238435,0.0000201947,0.000006957052,0.00001796899,0.00006325,0.000005601606,0.0004164122],"genre_scores_gemma":[0.9995957,0.0001095204,0.0000704298,0.00002087354,0.000008103292,0.000007847445,0.0001061703,0.000001205592,0.00008014362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009102091,"threshold_uncertainty_score":0.004813671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076123551630152,"score_gpt":0.3284511041344372,"score_spread":0.3076898686181356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}