{"id":"W7115573629","doi":"10.18609/vac.2025.009","title":"The future is now: AI-enabled RNA–LNP discovery","year":2025,"lang":"en","type":"article","venue":"Vaccine Insights","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Work (physics); Project commissioning; Key (lock); Pandemic; Perspective (graphical)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004056058,0.0006184953,0.0006192446,0.0004615542,0.0009841786,0.003638314,0.001040533,0.003812863,0.004922174],"category_scores_gemma":[0.004215003,0.0003776818,0.0005692635,0.0003511913,0.002126002,0.005217044,0.0009669882,0.007514662,0.002196496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001485851,"about_ca_system_score_gemma":0.001511589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006437381,"about_ca_topic_score_gemma":0.001618391,"domain_scores_codex":[0.9987205,0.000243108,0.00007945547,0.0002060128,0.0005845153,0.0001663966],"domain_scores_gemma":[0.9970154,0.001709954,0.0001698594,0.00007401744,0.0005778963,0.000452951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003907685,0.0001060522,0.0005012085,0.00154967,0.00007473511,0.0007217114,0.0004390345,0.001012464,0.047434,0.07674798,0.6536492,0.2173732],"study_design_scores_gemma":[0.00002041574,0.0001121087,0.000106038,0.0000880966,0.00002044177,0.0002828174,0.0001295109,0.0008004176,0.01034172,0.01492024,0.9731525,0.00002578459],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.007110857,0.3068879,0.03133471,0.3782287,0.2467517,0.00009503083,0.0003909275,0.001253766,0.02794629],"genre_scores_gemma":[0.1094199,0.3375971,0.02760292,0.264456,0.1267298,0.0002351032,0.0005242742,0.0008195923,0.1326152],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004922174,"threshold_uncertainty_score":0.0214507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003125735126513787,"score_gpt":0.2302805552797229,"score_spread":0.2271548201532091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}