{"id":"W7115592742","doi":"10.3390/genes16121507","title":"Exercise, APOE Genotype, and Testosterone Modulate Gut Microbiome–Cognition Associations in Prostate Cancer Survivors","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Knight Cancer Institute, Oregon Health and Science University","keywords":"Prostate cancer; Testosterone (patch); Microbiome; Saliva; Androgen deprivation therapy; Aerobic exercise; Randomized controlled trial; Gut microbiome; Androgen","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003217824,0.0002385233,0.0003232691,0.0002745311,0.0004533304,0.0004463866,0.0001731522,0.0002662671,0.001790088],"category_scores_gemma":[0.0009720859,0.0001578838,0.0003208194,0.0004937365,0.0001767318,0.0001937864,0.0002855746,0.0002870461,0.0001748055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178931,"about_ca_system_score_gemma":0.0003189341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006054718,"about_ca_topic_score_gemma":0.007532119,"domain_scores_codex":[0.9998249,0.00005265743,0.00001232412,0.00004240725,0.00002406376,0.00004363622],"domain_scores_gemma":[0.9996744,0.00006012337,0.0001190411,0.00002912949,0.00003937625,0.00007793694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006101924,0.0001442741,0.9951851,0.00001833599,0.0001184171,0.00003667458,0.0001221838,0.00004733319,0.0007616247,0.00001394781,0.00009665063,0.002845339],"study_design_scores_gemma":[0.000008636859,0.0002428321,0.9992279,0.00000417527,0.00005214866,0.00004846334,0.0001105288,0.00009806524,0.00007917231,0.00002399176,0.0001019154,0.000002096204],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994653,0.0001928076,0.00004357483,0.00001999433,0.000002698363,0.000005651764,0.0001300182,0.00000190767,0.0001379324],"genre_scores_gemma":[0.9996585,0.0000513267,0.00004673776,0.00001517809,0.000003934001,0.000005144885,0.00009621544,9.81497e-7,0.0001219964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006054718,"threshold_uncertainty_score":0.01203895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008195486700273783,"score_gpt":0.2658814410874324,"score_spread":0.2576859543871586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}