{"id":"W7115592742","doi":"10.3390/genes16121507","title":"Exercise, APOE Genotype, and Testosterone Modulate Gut Microbiome–Cognition Associations in Prostate Cancer Survivors","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Knight Cancer Institute, Oregon Health and Science University","keywords":"Prostate cancer; Testosterone (patch); Microbiome; Saliva; Androgen deprivation therapy; Aerobic exercise; Randomized controlled trial; Gut microbiome; Androgen","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032287,0.0001059102,0.0001269236,0.00008764893,0.00008470566,0.00002151353,0.00005789334,0.0001006213,0.000007327912],"category_scores_gemma":[0.000009895093,0.0001100312,0.00002309416,0.0001571501,0.00003534434,0.000003831955,0.00006836839,0.00005168337,0.000004936708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002370666,"about_ca_system_score_gemma":0.00009813531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008393849,"about_ca_topic_score_gemma":0.006501908,"domain_scores_codex":[0.9993029,0.00003106814,0.0001654361,0.0002572491,0.00003163543,0.000211695],"domain_scores_gemma":[0.9997179,0.000005402258,0.00005083484,0.0001254006,0.00006770508,0.00003275182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002634178,0.00003345624,0.0381222,0.00004922986,0.00001987412,7.097591e-7,0.0000780394,0.00002429082,0.9516831,0.000008202496,0.0005749654,0.009379615],"study_design_scores_gemma":[0.001231319,0.00007062197,0.6771719,0.0001421847,0.00005912319,0.000003458499,0.00009181962,0.00003395302,0.3011191,0.0002262816,0.019535,0.0003151245],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893134,0.009418694,0.00002684188,0.0004482424,0.0001622602,0.0002844084,0.0001215632,0.000009797837,0.0002148189],"genre_scores_gemma":[0.990276,0.006231225,0.0002901799,0.0003426727,0.00004051797,0.00004793493,0.0003390313,0.00001241968,0.002420005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6505639,"threshold_uncertainty_score":0.4486942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008195486700273783,"score_gpt":0.2658814410874324,"score_spread":0.2576859543871586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}