{"id":"W7115817562","doi":"","title":"EXPANDING THE TRUHD CELL LIBRARY OF HUNTINGTON’S DISEASE: CAPTURING THE PRODROMAL STAGE OF DISEASE AND EXAMINING HOW KINETIN AFFECTS HUNTINGTIN EXPRESSION","year":2024,"lang":"en","type":"dissertation","venue":"MacSphere (McMaster University)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Krembil Foundation","keywords":"Huntingtin; Huntington's disease; Huntingtin Protein; Apoptosis; DNA damage; Cell; Programmed cell death; Trinucleotide repeat expansion","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004093571,0.0006018196,0.0005442265,0.0006472052,0.0004834597,0.0005526782,0.0003867853,0.0003516399,0.003188414],"category_scores_gemma":[0.0002195915,0.0002257579,0.0004693665,0.000751432,0.0002124311,0.0002334482,0.0006030578,0.0007822515,0.002530478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004162792,"about_ca_system_score_gemma":0.0004953225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531613,"about_ca_topic_score_gemma":0.003927107,"domain_scores_codex":[0.9996725,0.00004153312,0.00003182609,0.00006339063,0.0001381073,0.000052638],"domain_scores_gemma":[0.9998085,0.00004591052,0.00001296941,0.00003561916,0.00006405,0.00003296533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005070559,0.00005190002,0.0002067365,0.00005002331,0.000005101317,0.00005992908,0.00003794545,0.00009848179,0.9904864,0.0001153835,0.0004453315,0.008392058],"study_design_scores_gemma":[0.00001779393,0.0003592051,0.003205456,0.00001253599,0.00003823691,0.0003090013,0.00004022217,0.0005947523,0.9731741,0.0000619248,0.02217145,0.00001522451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8041332,0.005458906,0.1381652,0.0008690081,0.0003706519,0.00130518,0.01799747,0.001621219,0.03007905],"genre_scores_gemma":[0.5945476,0.0111236,0.2172711,0.001276698,0.00008373707,0.001707209,0.07003219,0.001152836,0.102805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003188414,"threshold_uncertainty_score":0.01066625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689430139440688,"score_gpt":0.2102462248194181,"score_spread":0.1933519234250112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}