{"id":"W7115889519","doi":"10.64898/2025.12.16.25342400","title":"Associations of Epigenetic Age Acceleration with Motor Impairment: Evidence from the PPMI Cohort","year":2025,"lang":"en","type":"article","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute on Aging; National Institutes of Health","keywords":"Epigenetics; Cohort; Dopaminergic; Disease; Cohort study; Epigenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001530711,0.0002468697,0.0003381943,0.0005538706,0.0002754477,0.0005401408,0.0004164232,0.0002946201,0.001216174],"category_scores_gemma":[0.00564705,0.0001743612,0.0004694177,0.000712426,0.0002405986,0.000310282,0.0008216579,0.0004475041,0.0001214039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001830012,"about_ca_system_score_gemma":0.0002305687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005059156,"about_ca_topic_score_gemma":0.006792508,"domain_scores_codex":[0.9993817,0.0001194086,0.00005599124,0.0002873785,0.0001108983,0.00004462713],"domain_scores_gemma":[0.9977055,0.0004021472,0.0009480283,0.0004342626,0.0003318075,0.0001782477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002503134,0.00001292273,0.9926574,0.0000282491,0.0003890589,0.00006261697,0.0001018687,0.0001164885,0.0004069158,0.0000759763,0.0003437848,0.005554412],"study_design_scores_gemma":[0.000006209612,0.00004993584,0.9988841,0.00001073673,0.0001255664,0.0001369113,0.00004157857,0.0002151633,0.0001055907,0.0000652555,0.000355482,0.000003521111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950033,0.000922099,0.0006371701,0.0001227179,0.00001204507,0.00001129212,0.00252324,0.00002228318,0.0007457216],"genre_scores_gemma":[0.9977419,0.0003152593,0.0003118908,0.00003758895,0.00001536142,0.00001154646,0.00138393,0.000008056349,0.0001745309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005059156,"threshold_uncertainty_score":0.01005942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123380651742029,"score_gpt":0.2832503160913616,"score_spread":0.2620165095739413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}