{"id":"W7115902880","doi":"10.3390/antibiotics14121283","title":"Pathogen-Specific Actinium-225 and Lutetium-177 Labeled Antibodies for Treatment of Biofilm-Associated Implant Infections: Initial In Vivo Proof-of-Concept","year":2025,"lang":"en","type":"article","venue":"Antibiotics","topic":"Orthopedic Infections and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Universidad de Buenos Aires; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"In vivo; Implant; Context (archaeology); Antibody; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009847686,0.0001895278,0.0005452725,0.0003255214,0.0000906948,0.00001029283,0.00002222214,0.0001735136,0.00001634864],"category_scores_gemma":[0.00007755848,0.0001550312,0.0001178137,0.0003956169,0.000136486,0.00005065221,0.00002199288,0.0000573547,5.201042e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009775875,"about_ca_system_score_gemma":0.0001427943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001259693,"about_ca_topic_score_gemma":0.0001593063,"domain_scores_codex":[0.9989554,0.00003881985,0.0004431564,0.0002385128,0.00009507623,0.0002290621],"domain_scores_gemma":[0.9992455,0.0001820683,0.0001672512,0.0001927353,0.0001687656,0.00004363965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005211575,0.009220316,0.9001999,0.0004724718,0.001276239,0.00008359111,0.001260449,0.000011603,0.03465158,0.001716104,0.000563695,0.05002291],"study_design_scores_gemma":[0.01556448,0.006428251,0.1063435,0.0008539519,0.0008276984,0.00006978242,0.0005492829,0.0002110582,0.8600796,0.0001560018,0.008623969,0.000292422],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956467,0.0008379119,0.000194221,0.0001091309,0.0004506071,0.001067628,0.0004458619,0.00003040997,0.001217565],"genre_scores_gemma":[0.9974108,0.001272986,0.0006333023,0.00002470502,0.00004850926,0.000005715692,0.0001145109,0.00001566143,0.0004737487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.825428,"threshold_uncertainty_score":0.632199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287246657439931,"score_gpt":0.316738447803169,"score_spread":0.2938659812287697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}