{"id":"W7115950137","doi":"10.2147/jir.s565721","title":"Synthetic 1,3,6-Tri-O-Galloyl-α-D-Glucose Mimics the Hippo Pathway Inhibitor VT107 in Suppressing Concanavalin A-Induced Inflammation in Human Glioblastoma Cells","year":2025,"lang":"en","type":"article","venue":"Journal of Inflammation Research","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec - Clinical Research Organization in Cancer; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal; Université du Québec à Montréal","keywords":"Inflammation; Glioblastoma; Hippo signaling pathway; Concanavalin A; Signal transduction; Dual role","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005390273,0.0001881619,0.0002883904,0.0009073774,0.000221356,0.0001635364,0.0005212371,0.0003068936,0.00002214894],"category_scores_gemma":[0.001103474,0.0001522769,0.000131224,0.0007216777,0.000166327,0.00003778185,0.0001497868,0.0009113436,0.000009181163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050461,"about_ca_system_score_gemma":0.0007409746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000531938,"about_ca_topic_score_gemma":0.0005158169,"domain_scores_codex":[0.9963273,0.001129097,0.001132921,0.0002750893,0.000685883,0.0004496937],"domain_scores_gemma":[0.9981382,0.0002527537,0.0003753442,0.0003907247,0.0007440502,0.00009886422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002627864,0.00005849333,0.0006457968,0.00006785972,0.00002669889,0.00004372136,0.0005164327,0.001645299,0.9880143,0.0002292172,0.0001218981,0.008367437],"study_design_scores_gemma":[0.001264095,0.0003432827,0.0009081775,0.000482074,0.000007865058,0.00001235443,0.0006011694,0.001096435,0.9910443,0.0005777244,0.003521596,0.0001409055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969898,0.000343929,0.0001586227,0.001399676,0.0002291215,0.0003932533,0.00000376039,0.00000631583,0.0004754855],"genre_scores_gemma":[0.9989987,0.0001202707,0.00009671466,0.0000360585,0.0004579856,0.00002472294,0.00001139156,0.00002135684,0.0002327705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008226532,"threshold_uncertainty_score":0.6209671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639527442352813,"score_gpt":0.3323638690373482,"score_spread":0.3059685946138201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}