{"id":"W7116047683","doi":"10.1016/j.bpsgos.2025.100679","title":"Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry Global Open Science","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Advancing Translational Sciences; NIH Clinical Center; National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Mental Health; National Social Science Fund of China; Canadian Institutes of Health Research; VISN 4 Mental Illness Research, Education, and Clinical Center; Clinical Science Research and Development; Brain and Behavior Research Foundation; Rehabilitation Research and Development Service; National Natural Science Foundation of China; Foundation for Innovative Research Groups of the National Natural Science Foundation of China; National Institutes of Health; Fondation Pierre Deniker pour la Recherche et la Prévention en Santé Mentale; Ministerstvo Zdravotnictví Ceské Republiky; Institute for Clinical and Translational Research, University of Wisconsin, Madison; Natural Science Foundation of Jiangsu Province; Ministry of Education; Institute of Psychology, Chinese Academy of Sciences; Universiteit Gent; Congressionally Directed Medical Research Programs; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institute for Military and Veteran Health Research; National Alliance for Research on Schizophrenia and Depression; ZonMw; Chinese Academy of Sciences; Michael J. Fox Foundation for Parkinson's Research; Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions; Deutsche Forschungsgemeinschaft; Ministry of Education of the People's Republic of China; Dana Foundation; U.S. Department of Veterans Affairs; U.S. Department of Defense; National Science Foundation","keywords":"Ventromedial prefrontal cortex; Prefrontal cortex; Posttraumatic stress; Gyrification; Stress (linguistics); Frontal lobe","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007197207,0.0001629224,0.000243002,0.00005036316,0.0003458682,0.0001331675,0.003988537,0.00007271946,0.00005431568],"category_scores_gemma":[0.0006145629,0.0000957361,0.0000546419,0.00172864,0.0007223781,0.0004263465,0.0008275847,0.0001631883,0.00001042168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007048544,"about_ca_system_score_gemma":0.0002634969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009499709,"about_ca_topic_score_gemma":0.0005807853,"domain_scores_codex":[0.9974896,0.0004496202,0.0004418802,0.0008376864,0.0004297258,0.000351542],"domain_scores_gemma":[0.998939,0.00007860053,0.0001820373,0.000668473,0.0000358354,0.00009609106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006191585,0.007027754,0.3346642,0.00001824808,0.000003581805,0.000006695547,0.0002709473,0.0000503441,0.5999922,0.05342468,0.0000257778,0.003896448],"study_design_scores_gemma":[0.0007311695,0.001189034,0.9761531,0.00004383452,0.000006184597,0.000004027486,0.0009475208,0.0002545439,0.01227784,0.0082388,0.00001787231,0.0001360693],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992933,0.00002333482,0.00003695768,0.0005361565,0.002588256,0.001647006,0.00005579913,0.00002105476,0.002158417],"genre_scores_gemma":[0.9991403,0.000004965158,0.0001457023,0.000610947,0.00002074975,0.00004079356,0.000001231433,0.00000224615,0.00003307633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6414889,"threshold_uncertainty_score":0.7411762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.080437446750545,"score_gpt":0.3842824408268147,"score_spread":0.3038449940762697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}