{"id":"W7116047683","doi":"10.1016/j.bpsgos.2025.100679","title":"Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry Global Open Science","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Advancing Translational Sciences; NIH Clinical Center; National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Mental Health; National Social Science Fund of China; Canadian Institutes of Health Research; VISN 4 Mental Illness Research, Education, and Clinical Center; Clinical Science Research and Development; Brain and Behavior Research Foundation; Rehabilitation Research and Development Service; National Natural Science Foundation of China; Foundation for Innovative Research Groups of the National Natural Science Foundation of China; National Institutes of Health; Fondation Pierre Deniker pour la Recherche et la Prévention en Santé Mentale; Ministerstvo Zdravotnictví Ceské Republiky; Institute for Clinical and Translational Research, University of Wisconsin, Madison; Natural Science Foundation of Jiangsu Province; Ministry of Education; Institute of Psychology, Chinese Academy of Sciences; Universiteit Gent; Congressionally Directed Medical Research Programs; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institute for Military and Veteran Health Research; National Alliance for Research on Schizophrenia and Depression; ZonMw; Chinese Academy of Sciences; Michael J. Fox Foundation for Parkinson's Research; Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions; Deutsche Forschungsgemeinschaft; Ministry of Education of the People's Republic of China; Dana Foundation; U.S. Department of Veterans Affairs; U.S. Department of Defense; National Science Foundation","keywords":"Ventromedial prefrontal cortex; Prefrontal cortex; Posttraumatic stress; Gyrification; Stress (linguistics); Frontal lobe","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001519436,0.0005163266,0.0005073347,0.0004893978,0.0005215033,0.000873631,0.0007540603,0.0005359877,0.003100101],"category_scores_gemma":[0.002790215,0.0003514772,0.001548817,0.0008388619,0.0004005076,0.0005397378,0.0007713072,0.0006267222,0.000220282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003968893,"about_ca_system_score_gemma":0.0004898508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006657926,"about_ca_topic_score_gemma":0.007365877,"domain_scores_codex":[0.9995881,0.0000951357,0.00003443582,0.0001900642,0.00003975248,0.00005244606],"domain_scores_gemma":[0.9987699,0.0002630384,0.0005595481,0.0001776693,0.0001121617,0.0001176026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001988694,0.00006015971,0.9832955,0.0004028685,0.005033589,0.0002780136,0.0004853842,0.0002067942,0.001118551,0.000283785,0.0007337695,0.00611293],"study_design_scores_gemma":[0.00007798477,0.0001131794,0.9954782,0.00006027305,0.001973649,0.0004187615,0.0002799916,0.00021804,0.0001537536,0.0003657682,0.000850045,0.00001050203],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991725,0.00535524,0.0004290848,0.0003332152,0.00003842418,0.00002412342,0.001360546,0.00001000582,0.0007243701],"genre_scores_gemma":[0.9987018,0.0003582127,0.0002102916,0.00004993963,0.00002111184,0.00001430534,0.0004202819,0.000005640783,0.0002183781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006657926,"threshold_uncertainty_score":0.01323837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.080437446750545,"score_gpt":0.3842824408268147,"score_spread":0.3038449940762697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}