{"id":"W7116204116","doi":"10.64898/2025.12.16.694702","title":"STING–IFN–CH25H lipid axis links innate immune activation to tau pathology","year":2025,"lang":"en","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Innate immune system; Neurodegeneration; Oxysterol; Signal transduction; Apoptosis; Immune system; Lipid signaling; Lipid metabolism; Mitochondrion; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488823,0.0003872917,0.0001633807,0.0002957873,0.0001825571,0.0002943652,0.000093363,0.0002451543,0.001054819],"category_scores_gemma":[0.00006604836,0.00009026524,0.000152212,0.0000965875,0.0003486194,0.0001677581,0.0002119335,0.0004990527,0.0001688072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004238108,"about_ca_system_score_gemma":0.000285396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006226259,"about_ca_topic_score_gemma":0.001177283,"domain_scores_codex":[0.9999193,0.0000122795,0.000006823607,0.00001886682,0.00001902491,0.00002368253],"domain_scores_gemma":[0.9999504,0.000002777316,0.00002150025,0.000004937022,0.000005404112,0.00001510866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003684446,0.00002155591,0.002201448,0.00004323034,0.00001419018,0.0001969635,0.00003275082,0.0001326348,0.9908009,0.000458579,0.0001334944,0.005595895],"study_design_scores_gemma":[0.00004555437,0.0004547592,0.05281831,0.00004694282,0.00007971159,0.0009682581,0.0001547561,0.002549311,0.9357883,0.001299396,0.005781069,0.00001362668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916306,0.00363451,0.001994342,0.0002858044,0.00003961847,0.00001678472,0.0003390638,0.00009440706,0.001964962],"genre_scores_gemma":[0.9967871,0.001098566,0.0007090628,0.0000571501,0.00001533674,0.00000860617,0.0001490947,0.000005736204,0.001169321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054819,"threshold_uncertainty_score":0.003528714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00854149768681394,"score_gpt":0.2245971148574752,"score_spread":0.2160556171706613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}