{"id":"W7116394069","doi":"10.64898/2025.12.18.25342588","title":"Amyloid and tau pathologies are drivers of white matter damage in aging and Alzheimer’s disease","year":2025,"lang":"en","type":"article","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer Society; Natural Sciences and Engineering Research Council of Canada; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Biogen; Eisai; Alzheimer Society Research Program; Alzheimer's Association; Canadian Institutes of Health Research; Réseau en Bio-Imagerie du Quebec","keywords":"Disease; Amyloid (mycology); White matter; Degenerative disease; Amyloid β; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006637,0.0004655755,0.0003992374,0.0008416393,0.000418054,0.00108271,0.000308593,0.0004375291,0.001478612],"category_scores_gemma":[0.003078854,0.0003301801,0.000462145,0.001149355,0.0003778606,0.0007859438,0.0007257198,0.0006067823,0.0002096739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637669,"about_ca_system_score_gemma":0.0004416512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004142353,"about_ca_topic_score_gemma":0.004468009,"domain_scores_codex":[0.999656,0.00008843403,0.00003207533,0.0001129195,0.00006656844,0.00004402651],"domain_scores_gemma":[0.9980952,0.0002932071,0.00108354,0.0001370276,0.0002173625,0.0001736547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001807742,0.00005578052,0.9914506,0.00003309656,0.0002219013,0.00008694853,0.0001660053,0.0001739879,0.00102513,0.0002088996,0.000168765,0.00622795],"study_design_scores_gemma":[0.000002785171,0.00003867581,0.998466,0.00001172332,0.00005362302,0.0001036065,0.00009468018,0.0003368124,0.0001364651,0.0005617514,0.000190432,0.000003534373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955433,0.002572621,0.0003662274,0.0002361371,0.00001924712,0.000006029823,0.0002570199,0.00001136962,0.000987956],"genre_scores_gemma":[0.9981817,0.0009593396,0.0002751345,0.0000326652,0.00004834473,0.000006374908,0.0001908876,0.000003112778,0.0003025675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004142353,"threshold_uncertainty_score":0.008236468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186313158778959,"score_gpt":0.3032302830521558,"score_spread":0.2813671514643662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}