{"id":"W7116516733","doi":"10.1016/j.tox.2025.154375","title":"Transcriptomic analysis of BPA alternative chemicals in primary human mammary epithelial cells","year":2025,"lang":"en","type":"article","venue":"Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada; Canada Research Chairs; Ontario Research Foundation","keywords":"Transcriptome; Gene expression; Estrogen receptor; Bisphenol; Estrogen receptor alpha; In vitro; Gene; Endocrine disruptor; Benzhydryl compounds; Bisphenol A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009792845,0.0002456593,0.0003723932,0.0005101811,0.0003914163,0.0004486604,0.0001260519,0.0002659811,0.002003899],"category_scores_gemma":[0.0001701438,0.0001431595,0.000485497,0.0008940367,0.000151537,0.0001858121,0.0002855027,0.0003746347,0.000558298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639347,"about_ca_system_score_gemma":0.0003832777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002193093,"about_ca_topic_score_gemma":0.003412409,"domain_scores_codex":[0.9998081,0.00001238123,0.00001151696,0.00006020807,0.00006491,0.00004280571],"domain_scores_gemma":[0.999923,0.00002072847,0.00001254808,0.000005738867,0.00002847756,0.000009526278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306271,0.000009708332,0.001302794,0.00008143485,0.00001546934,0.0000627944,0.0000280763,0.00005453753,0.9965521,0.00004559067,0.00009274475,0.001624174],"study_design_scores_gemma":[0.00002459635,0.0005733389,0.2625242,0.00005179421,0.0002505697,0.0009090492,0.0009201289,0.002208522,0.7122962,0.0002661835,0.01994229,0.00003308333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489559,0.00493032,0.006959878,0.000391213,0.0001386248,0.0001063961,0.03318098,0.0001227394,0.005213986],"genre_scores_gemma":[0.9296795,0.006148546,0.008115446,0.0005774743,0.00007589428,0.0003138805,0.0410572,0.00006716766,0.01396476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002193093,"threshold_uncertainty_score":0.006703734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007349570086482315,"score_gpt":0.3200911847724736,"score_spread":0.3127416146859913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}