{"id":"W7116516733","doi":"10.1016/j.tox.2025.154375","title":"Transcriptomic analysis of BPA alternative chemicals in primary human mammary epithelial cells","year":2025,"lang":"en","type":"article","venue":"Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada; Canada Research Chairs; Ontario Research Foundation","keywords":"Transcriptome; Gene expression; Estrogen receptor; Bisphenol; Estrogen receptor alpha; In vitro; Gene; Endocrine disruptor; Benzhydryl compounds; Bisphenol A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046407,0.0001237998,0.0004407278,0.0001904103,0.00002909371,0.000005113829,0.0003645836,0.00009360992,0.0005973066],"category_scores_gemma":[0.00002672598,0.0001105143,0.0001486239,0.0006048311,0.0002297621,0.00005665948,0.0001612733,0.0001570436,0.00001661694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515777,"about_ca_system_score_gemma":0.00001147039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003702794,"about_ca_topic_score_gemma":0.0001792798,"domain_scores_codex":[0.9988843,0.00008510095,0.0003442687,0.0003219455,0.0001048048,0.0002595462],"domain_scores_gemma":[0.9994422,0.0001837294,0.00008961603,0.0002379344,0.000005642826,0.00004092514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002419064,0.000217569,0.01779086,0.00001725183,0.000141968,0.00001218613,0.0001307677,0.0006363249,0.9788529,0.0003931342,0.000457921,0.001324963],"study_design_scores_gemma":[0.0006927797,0.00006364817,0.1135272,0.00001124802,0.0002017161,6.622473e-7,0.00001397085,0.0005204662,0.8825701,0.001378818,0.0008838146,0.0001355318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786724,0.00004113412,0.0001888742,0.0002404304,0.00008006289,0.0001551768,0.00001682498,0.0000174084,0.0205877],"genre_scores_gemma":[0.9982229,0.00002932311,0.0004984016,0.0004694116,0.00001111706,0.0000180047,0.00001746264,0.00000557393,0.0007277614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09628273,"threshold_uncertainty_score":0.6540089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007349570086482315,"score_gpt":0.3200911847724736,"score_spread":0.3127416146859913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}