{"id":"W7116631937","doi":"10.1016/j.esmorc.2025.100070","title":"EXPLORING ACTIONABLE THERAPEUTIC TARGETS ASSOCIATED WITH SMARCB1 DEFICIENCY IN EPITHELIOID SARCOMA","year":2025,"lang":"en","type":"article","venue":"ESMO rare cancers.","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Epithelioid sarcoma; Sarcoma; SMARCB1; Disease; Mutation; Soft tissue sarcoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004508127,0.0003146863,0.0004570017,0.000357116,0.0001819645,0.0007462089,0.0003681598,0.0004681221,0.002461028],"category_scores_gemma":[0.0002380873,0.0001547136,0.0003032112,0.0002947323,0.0003127136,0.0003789407,0.0003088152,0.0008614332,0.0004880976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000490547,"about_ca_system_score_gemma":0.0004007564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002876927,"about_ca_topic_score_gemma":0.0008890514,"domain_scores_codex":[0.9998715,0.00003152199,0.000008590752,0.00001990359,0.00002876094,0.00003970619],"domain_scores_gemma":[0.9999248,0.00002015596,0.00002038674,0.000007327233,0.00001140436,0.00001588895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001751628,0.0003895983,0.003376775,0.001264656,0.000128295,0.0009052555,0.0001351609,0.00203999,0.8468226,0.007567442,0.003242918,0.1323757],"study_design_scores_gemma":[0.0009539648,0.006387236,0.01780119,0.0005492888,0.000525424,0.004667094,0.0005935156,0.00599417,0.7634373,0.006702105,0.1923247,0.0000642022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7033654,0.2555948,0.01444546,0.004681218,0.0004354313,0.0002920805,0.001044514,0.0003313857,0.01980971],"genre_scores_gemma":[0.9398694,0.0514513,0.003410093,0.0006710876,0.00008956218,0.0001509474,0.0006549539,0.00002762396,0.003675025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002461028,"threshold_uncertainty_score":0.008232892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03014984236719089,"score_gpt":0.2573838991908916,"score_spread":0.2272340568237007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}