{"id":"W7116631937","doi":"10.1016/j.esmorc.2025.100070","title":"EXPLORING ACTIONABLE THERAPEUTIC TARGETS ASSOCIATED WITH SMARCB1 DEFICIENCY IN EPITHELIOID SARCOMA","year":2025,"lang":"en","type":"article","venue":"ESMO rare cancers.","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Epithelioid sarcoma; Sarcoma; SMARCB1; Disease; Mutation; Soft tissue sarcoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252297,0.0001396993,0.0001397257,0.00007233509,0.00009434142,0.00001842697,0.0001441113,0.00008019374,0.00003489962],"category_scores_gemma":[0.0000364271,0.0001264879,0.00004731418,0.0002858216,0.0000482378,0.000009284859,0.00003776481,0.0001233176,0.00000257189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427245,"about_ca_system_score_gemma":0.0003733738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000249749,"about_ca_topic_score_gemma":0.0008766648,"domain_scores_codex":[0.9990999,0.00004136694,0.0001525639,0.0003169191,0.0001135825,0.0002756288],"domain_scores_gemma":[0.9996009,0.00001618174,0.0000536296,0.0002288101,0.00006761602,0.00003284589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002270061,0.0009325102,0.169047,0.0005838198,0.00127643,0.0001028571,0.002767765,0.1027318,0.4791807,0.001987486,0.01560081,0.2235187],"study_design_scores_gemma":[0.01020756,0.001198382,0.19941,0.001578722,0.0001883698,0.00002648427,0.003345033,0.006479945,0.6427519,0.001719255,0.130879,0.002215347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870236,0.005558317,0.001336296,0.0002610041,0.0002799279,0.0001588988,0.00001243914,0.00003259756,0.005336915],"genre_scores_gemma":[0.9974676,0.0005759239,0.0001172385,0.0004380078,0.00005554461,0.0001127402,0.0000520081,0.00001770305,0.001163196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2213034,"threshold_uncertainty_score":0.5158027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03014984236719089,"score_gpt":0.2573838991908916,"score_spread":0.2272340568237007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}