{"id":"W7116663774","doi":"10.1200/po-25-00221","title":"CRESTONE: A Phase II Study of the Efficacy and Safety of the HER3 Monoclonal Antibody, Seribantumab, in Solid Tumors With Neuregulin-1 ( <i>NRG1</i> ) Fusions","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"National Cancer Institute","keywords":"Monoclonal antibody; Solid tumor; Phase (matter); Cancer; Antibody; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002052989,0.001266972,0.001245268,0.0003911734,0.0003576705,0.0008678499,0.000757211,0.0009187147,0.002034399],"category_scores_gemma":[0.001010839,0.0004046618,0.001156223,0.0002694702,0.0009614203,0.0005346279,0.000424705,0.001734082,0.0004526177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006516665,"about_ca_system_score_gemma":0.001538039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069332,"about_ca_topic_score_gemma":0.003459915,"domain_scores_codex":[0.9993871,0.0002760749,0.00003757751,0.00009483723,0.0001154578,0.00008898952],"domain_scores_gemma":[0.9991809,0.0001394333,0.0001745664,0.00007112732,0.00007082948,0.0003630554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6949934,0.05543694,0.02020468,0.002033502,0.002290326,0.0006514027,0.0006287477,0.005681086,0.114034,0.0008786857,0.004549049,0.09861832],"study_design_scores_gemma":[0.4598805,0.4861862,0.03326177,0.00007119249,0.001428245,0.0006844116,0.00009543914,0.002887442,0.01038983,0.000224007,0.004811038,0.00007992846],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937574,0.001177045,0.000551423,0.000164084,0.00005400254,0.001852775,0.0007132028,0.00005877965,0.00167132],"genre_scores_gemma":[0.9925034,0.001060568,0.001286755,0.0004245369,0.00007181599,0.001249971,0.001520519,0.0000140008,0.001868469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052989,"threshold_uncertainty_score":0.0108574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666193238864297,"score_gpt":0.4291821007089544,"score_spread":0.4025201683203114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}