{"id":"W7116663774","doi":"10.1200/po-25-00221","title":"CRESTONE: A Phase II Study of the Efficacy and Safety of the HER3 Monoclonal Antibody, Seribantumab, in Solid Tumors With Neuregulin-1 ( <i>NRG1</i> ) Fusions","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"National Cancer Institute","keywords":"Monoclonal antibody; Solid tumor; Phase (matter); Cancer; Antibody; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020077,0.0001888171,0.0007385035,0.000211115,0.0002168478,0.000006579759,0.0004934437,0.0001593894,0.0000941908],"category_scores_gemma":[0.0007768149,0.00009955046,0.00008110169,0.00110005,0.0005496825,0.00003817536,0.0009470712,0.0007412292,0.000001204153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818195,"about_ca_system_score_gemma":0.001481209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003258827,"about_ca_topic_score_gemma":0.001084544,"domain_scores_codex":[0.9971839,0.0006982777,0.0007500551,0.0004267943,0.0006200936,0.0003208952],"domain_scores_gemma":[0.9974754,0.001054739,0.0002486683,0.0008823347,0.0002405021,0.00009834477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05572716,0.03959482,0.4124549,0.0005288325,0.0004981459,0.000401593,0.01495572,0.001284507,0.2132316,0.0005964258,0.01066787,0.2500584],"study_design_scores_gemma":[0.03992865,0.02073255,0.9030448,0.001605349,0.0002076186,0.000170246,0.001842346,0.0009781234,0.01195296,0.0002165582,0.01913043,0.0001904274],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889697,0.0002714473,0.00002499755,0.00558309,0.0002593011,0.002611891,0.00002098561,0.0000136215,0.002244907],"genre_scores_gemma":[0.9983457,0.0001414047,0.0001402386,0.0003823197,0.00004039863,0.00006575418,0.000002717225,0.00001924008,0.000862233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4905898,"threshold_uncertainty_score":0.405955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666193238864297,"score_gpt":0.4291821007089544,"score_spread":0.4025201683203114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}