{"id":"W7116671186","doi":"10.1093/nar/gkaf1358","title":"Casδ, an evolutionary transitional CRISPR system enables efficient genome editing across animals and plants","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China","keywords":"CRISPR; Genome editing; Indel; Genome; Nuclease; Homing endonuclease; INDEL Mutation; Effector; Palindrome; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759132,0.0005215985,0.0004649852,0.0006297127,0.0003985126,0.0005409865,0.0006818674,0.0003423385,0.001488892],"category_scores_gemma":[0.0002573757,0.0002427283,0.0003628546,0.0004725505,0.0003205008,0.0003619827,0.0006560361,0.0007496522,0.001006292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000475548,"about_ca_system_score_gemma":0.0004644532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008257905,"about_ca_topic_score_gemma":0.001372857,"domain_scores_codex":[0.9997279,0.00002283241,0.00002981797,0.00009312641,0.00008990134,0.00003642055],"domain_scores_gemma":[0.9998717,0.00001397106,0.00004085506,0.00002619399,0.00001827054,0.00002894774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001931403,0.00002928914,0.001026289,0.0001307021,0.00002941449,0.0001433062,0.00004025349,0.0005446577,0.9711594,0.001431519,0.0007971617,0.02447494],"study_design_scores_gemma":[0.00004519539,0.0003947502,0.007415389,0.00002837701,0.00007391986,0.001663227,0.0000627589,0.005386379,0.9238346,0.0007580836,0.06029525,0.00004219002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7823336,0.005397303,0.176657,0.0003597623,0.0002533419,0.0005243444,0.007984851,0.008911417,0.01757848],"genre_scores_gemma":[0.8910519,0.001939988,0.07734995,0.0002141213,0.0000241356,0.0002291403,0.01027496,0.0003906155,0.01852515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488892,"threshold_uncertainty_score":0.004980862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981909272749843,"score_gpt":0.3689650277608523,"score_spread":0.3491459350333538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}