{"id":"W7116671337","doi":"10.1186/s13024-025-00918-w","title":"Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models","year":2025,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Harrington Discovery Institute, University Hospitals; National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; University of Toronto","keywords":"Neuropathology; Druggability; Disease; Function (biology); Neurology; Molecular medicine; Neurochemistry; Human physiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006780298,0.0001960574,0.0002051677,0.0002848135,0.0001072619,0.00005988369,0.00003862422,0.00006830194,0.000007819235],"category_scores_gemma":[0.0001137229,0.0001959326,0.00007096379,0.0002004765,0.00002877913,0.0001883908,0.00004982615,0.0001514241,0.00001025834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007254863,"about_ca_system_score_gemma":0.00005910668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003406271,"about_ca_topic_score_gemma":0.00002537291,"domain_scores_codex":[0.9986206,0.0001860316,0.0002649744,0.0005594828,0.0001678128,0.0002011131],"domain_scores_gemma":[0.9994621,0.00002399875,0.00007176869,0.0002607031,0.00005723924,0.0001241969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003557234,0.0008263561,0.04531432,0.0001749927,0.0001047026,0.001570923,0.0001211228,0.01107575,0.9056942,0.006553454,0.0002623091,0.02474459],"study_design_scores_gemma":[0.00907678,0.0008918044,0.5128154,0.0003711579,0.001313802,0.00006443859,0.00006482376,0.3762635,0.07795506,0.01008189,0.01044159,0.0006597379],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786642,0.0009228114,0.01799923,0.0009974254,0.0007599684,0.0004607975,0.000006690857,0.00006864365,0.0001202766],"genre_scores_gemma":[0.9979195,0.0001063994,0.0004311904,0.001068056,0.0001038494,0.0001075059,0.0001439119,0.00002805484,0.0000915506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8277392,"threshold_uncertainty_score":0.79899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542769282435582,"score_gpt":0.2647861024799424,"score_spread":0.2493584096555866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}