{"id":"W7116688526","doi":"10.1200/po-25-00507","title":"Master Protocol Design With Hybrid Control for Efficient Early-Phase Trial Consolidation","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Protocol (science); Consolidation (business); Control (management); Hybrid system; Bayesian probability; Control system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.105277,0.001867078,0.002563623,0.001809718,0.0007908892,0.00268115,0.003431351,0.002118043,0.01903009],"category_scores_gemma":[0.1635846,0.001357373,0.002316746,0.001191927,0.003034707,0.004089504,0.004942247,0.004308481,0.002378055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00187242,"about_ca_system_score_gemma":0.005953628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003913476,"about_ca_topic_score_gemma":0.0004473137,"domain_scores_codex":[0.9129585,0.06925257,0.004895988,0.006975072,0.004843796,0.001074048],"domain_scores_gemma":[0.8740991,0.08218434,0.01165008,0.02149016,0.00794202,0.002634405],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0438251,0.002081644,0.007316512,0.003232586,0.002970016,0.0003586741,0.001374782,0.08795893,0.01469241,0.1940572,0.01259106,0.6295411],"study_design_scores_gemma":[0.03748477,0.02411455,0.005830602,0.001151891,0.00270388,0.0004764352,0.0002855362,0.5506126,0.02694999,0.2720399,0.07797285,0.000376887],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01686428,0.0008453138,0.9539095,0.0006885178,0.0006164105,0.02094111,0.0003913094,0.002074895,0.003668792],"genre_scores_gemma":[0.2655971,0.0003272198,0.6621623,0.001036674,0.0004613498,0.06614055,0.0005099581,0.0003410523,0.003423805],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.8947231,"threshold_uncertainty_score":0.5567645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5109775295074659,"score_gpt":0.6108634696134609,"score_spread":0.09988594010599505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}