{"id":"W7116705329","doi":"10.1002/pro.70412","title":"Structural basis of product recognition by <i>Mycobacterium tuberculosis</i> fatty acid synthase","year":2025,"lang":"en","type":"article","venue":"Protein Science","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Fatty acid synthase; Fatty acid; Acyl carrier protein; Saccharomyces cerevisiae; Yeast; Cofactor; Transferase; Coenzyme A; Mycobacterium tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599193,0.0001033922,0.000115182,0.00004628461,0.0002337389,0.00005739856,0.0003711648,0.00003321784,0.0003771424],"category_scores_gemma":[0.0001229736,0.00009066047,0.00004111862,0.0005563318,0.0004252504,0.0002209304,0.0001175042,0.00009200554,0.00001616815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004366787,"about_ca_system_score_gemma":0.0001050607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006920298,"about_ca_topic_score_gemma":0.000002098083,"domain_scores_codex":[0.9989792,0.000007690388,0.0002140081,0.0003948501,0.0001912411,0.000213077],"domain_scores_gemma":[0.9993396,0.000009521591,0.0001001678,0.0003336167,0.0001652255,0.00005179973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007415721,0.00003509944,0.0003970749,0.00009842207,0.000004473904,1.411476e-7,0.00002345545,4.11576e-7,0.9790847,0.00009352496,0.0003738744,0.01988145],"study_design_scores_gemma":[0.00009640316,0.000004573521,0.0003483801,0.00009770082,0.00001240272,0.000001499344,0.00002335238,0.00005922277,0.9979926,0.0003236783,0.0009382754,0.0001018854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933972,0.00007954721,0.0003975502,0.0008390026,0.00004847849,0.0002406298,0.0001876785,0.00004418,0.004765676],"genre_scores_gemma":[0.9971772,0.000009838061,0.00215366,0.00008149177,0.00002676986,0.00008171159,0.00002861366,0.000004948313,0.0004357541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01977956,"threshold_uncertainty_score":0.4129445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228917493996739,"score_gpt":0.2494949339459809,"score_spread":0.2372057590060135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}