{"id":"W7116705329","doi":"10.1002/pro.70412","title":"Structural basis of product recognition by <i>Mycobacterium tuberculosis</i> fatty acid synthase","year":2025,"lang":"en","type":"article","venue":"Protein Science","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Fatty acid synthase; Fatty acid; Acyl carrier protein; Saccharomyces cerevisiae; Yeast; Cofactor; Transferase; Coenzyme A; Mycobacterium tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006513709,0.0001764732,0.0001155972,0.00005222995,0.0002041905,0.0003285821,0.0002905077,0.0003223001,0.0006005238],"category_scores_gemma":[0.0001905713,0.0001178781,0.0001355364,0.00006370059,0.000244671,0.0002212185,0.0001489448,0.0004420552,0.0002939695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003950446,"about_ca_system_score_gemma":0.0002376054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007004383,"about_ca_topic_score_gemma":0.0004885976,"domain_scores_codex":[0.9999421,0.00001025562,0.000003353596,0.00001526035,0.0000126957,0.00001631044],"domain_scores_gemma":[0.9999232,0.00001413099,0.00002464295,0.000006308634,0.00001034491,0.00002126814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002969711,0.00005357503,0.002107616,0.00006952397,0.000009045554,0.0004926346,0.00009712264,0.001690391,0.9899083,0.003116548,0.0001326031,0.002025558],"study_design_scores_gemma":[0.00008864932,0.0005184881,0.01269553,0.00002864143,0.00002887526,0.0009762587,0.0002749602,0.02327565,0.9536543,0.002684654,0.005741448,0.00003249454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950855,0.0004290661,0.002728344,0.000143147,0.00001341034,0.000007017139,0.0000465537,0.00004304155,0.001503897],"genre_scores_gemma":[0.9987382,0.00009999521,0.0008092613,0.0000270317,0.00000244995,0.000002262648,0.00008268892,0.000004489521,0.0002335187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007004383,"threshold_uncertainty_score":0.002866268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228917493996739,"score_gpt":0.2494949339459809,"score_spread":0.2372057590060135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}