{"id":"W7116716643","doi":"10.64898/2025.12.17.25342484","title":"Association of Brain Structural Measurements and Polygenic Risk Scores with Obsessive-Compulsive Symptoms in Adolescents Diagnosed with Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tic Disorders","year":2025,"lang":"en","type":"article","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Hospital for Sick Children","funders":"National Institutes of Health; Alberta Innovates","keywords":"Mendelian randomization; Autism; Association (psychology); Anxiety; Polygenic risk score; Orbitofrontal cortex; Neuroimaging; Inferior parietal lobule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003185952,0.0003000271,0.0001859195,0.0007459807,0.0002175538,0.0003121596,0.000228564,0.0003294905,0.001222454],"category_scores_gemma":[0.001594461,0.0002309038,0.0002648106,0.0004713705,0.0003488983,0.0001291818,0.0003479686,0.0003670482,0.00006478016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001556015,"about_ca_system_score_gemma":0.0001611671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003741737,"about_ca_topic_score_gemma":0.004937971,"domain_scores_codex":[0.9996718,0.00009146849,0.00003291158,0.0001132675,0.00004852628,0.00004202604],"domain_scores_gemma":[0.9990288,0.0002715377,0.0004449128,0.00008762465,0.00005540286,0.0001117285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007988435,0.00002001952,0.9969504,0.000003623991,0.00009787291,0.0001232071,0.0000692892,0.0000471075,0.001759551,0.00002553192,0.00001754166,0.0008059018],"study_design_scores_gemma":[0.00000274291,0.00003301091,0.9994001,0.000001090657,0.00001851056,0.0002833912,0.00003810447,0.0001017235,0.00009164015,0.00001431253,0.00001442958,8.958366e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999843,0.00002777787,0.00004669039,0.000005796529,5.788771e-7,0.000001318254,0.00003395408,0.000001262721,0.00003956339],"genre_scores_gemma":[0.9997999,0.00001739857,0.00006699003,0.000003488183,0.00000133154,0.000002885585,0.00007432716,0.000001161134,0.0000325741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003741737,"threshold_uncertainty_score":0.007439911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005516917498749541,"score_gpt":0.2541993271150112,"score_spread":0.2486824096162616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}