{"id":"W7116719518","doi":"10.3390/cancers18010031","title":"Advances and Challenges in KRAS Mutation Detection and Clinical Implications","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary; University of Victoria","funders":"","keywords":"KRAS; Mutation; Drug development; Cancer; Gene; Gene mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02361607,0.001144886,0.002120974,0.00363876,0.0008145657,0.004810068,0.002591183,0.004073303,0.007054748],"category_scores_gemma":[0.02977031,0.0006338143,0.001273775,0.002191315,0.003574267,0.006739341,0.002277203,0.00629546,0.004098808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002060441,"about_ca_system_score_gemma":0.004848641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002137011,"about_ca_topic_score_gemma":0.002838336,"domain_scores_codex":[0.9923041,0.002670366,0.0008512199,0.001418437,0.002400684,0.0003551221],"domain_scores_gemma":[0.9614262,0.02515836,0.001558228,0.001520679,0.009149388,0.001187126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002801411,0.0001509167,0.0056185,0.006479274,0.0001159339,0.0008033402,0.0004991257,0.001023866,0.004644517,0.02052551,0.03766141,0.9221975],"study_design_scores_gemma":[0.0000432641,0.0006144206,0.008197917,0.009405711,0.0003030506,0.01021853,0.002475721,0.002870969,0.006183659,0.07255294,0.8868722,0.0002615793],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0030945,0.9112399,0.01407902,0.06141937,0.002576634,0.00003855144,0.0002845476,0.0001950626,0.007072311],"genre_scores_gemma":[0.03911789,0.9019077,0.0299079,0.01692687,0.008352705,0.000131846,0.0005432091,0.0001322303,0.002979612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02361607,"threshold_uncertainty_score":0.1248952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02907416468628565,"score_gpt":0.3295808058454592,"score_spread":0.3005066411591735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}