{"id":"W7116719518","doi":"10.3390/cancers18010031","title":"Advances and Challenges in KRAS Mutation Detection and Clinical Implications","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary; University of Victoria","funders":"","keywords":"KRAS; Mutation; Drug development; Cancer; Gene; Gene mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009046491,0.00003657905,0.00004583269,0.00002919044,0.00003182486,0.000005618993,0.0000165152,0.00005226453,6.997185e-7],"category_scores_gemma":[0.00004193091,0.00003812572,0.00001091423,0.00004134752,0.00004590919,0.000003347393,0.00001418719,0.00002872079,1.451607e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002636656,"about_ca_system_score_gemma":0.00005126116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001286299,"about_ca_topic_score_gemma":0.0004125501,"domain_scores_codex":[0.9996725,0.00002360919,0.00008857948,0.0001507947,0.00001557011,0.00004897685],"domain_scores_gemma":[0.9998677,0.000009757542,0.00002415809,0.00006135993,0.00001773543,0.0000193148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00004005447,0.000004927814,0.004102981,0.00005563473,0.00001071463,3.762972e-7,0.0000231173,0.0001607928,0.03405339,0.0008480867,0.00000958884,0.9606903],"study_design_scores_gemma":[0.003658561,0.0004817759,0.4990856,0.0002316525,0.00006540942,0.00002311497,0.0009012397,0.004328724,0.176252,0.01281806,0.3016117,0.0005422115],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9076106,0.08467407,0.004592298,0.001356086,0.0001064662,0.0002091412,0.000003059033,0.00001065195,0.001437614],"genre_scores_gemma":[0.9682105,0.03148913,0.0001346215,0.00008172837,0.00003247279,0.00002421963,0.000004785406,0.000002234688,0.00002031637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9601481,"threshold_uncertainty_score":0.1554722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02907416468628565,"score_gpt":0.3295808058454592,"score_spread":0.3005066411591735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}