{"id":"W7116731164","doi":"10.1038/s41392-025-02507-1","title":"YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Chinese University of Hong Kong; Research Grants Council, University Grants Committee; National Natural Science Foundation of China","keywords":"Oxaliplatin; Colorectal cancer; Carcinogenesis; Gene knockdown; LGR5; Cancer stem cell; Apoptosis; Chemotherapy; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002794358,0.0001589396,0.0001349891,0.00006196939,0.0001891999,0.00004402741,0.0001268904,0.0001370417,0.0001561567],"category_scores_gemma":[0.000005015883,0.0001205177,0.00006073525,0.000226844,0.00009735396,0.00001005991,0.000006940205,0.000136504,5.677232e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002517722,"about_ca_system_score_gemma":0.0001132289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007499829,"about_ca_topic_score_gemma":0.00004348914,"domain_scores_codex":[0.9989839,0.0002075963,0.0001911369,0.0003256478,0.0000936819,0.0001980823],"domain_scores_gemma":[0.9996916,0.00002229638,0.00004737802,0.0001448503,0.00005729181,0.00003658093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002392832,0.00007550617,0.0007162025,0.000005142335,0.00006536066,3.567162e-7,0.0003309886,0.000066511,0.9710831,0.00002254284,0.0009645655,0.02427688],"study_design_scores_gemma":[0.001641753,0.0001242373,0.01241537,0.00001607123,0.000005995891,0.000002111114,0.0002356897,0.0001339397,0.9289299,0.0000799023,0.05626626,0.0001487465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819659,0.01120916,0.001410394,0.00470136,0.0002378688,0.0003339286,0.00003001372,0.00001540551,0.00009596929],"genre_scores_gemma":[0.9949834,0.003353222,0.00003259937,0.000756142,0.0000754084,0.0001665984,0.00003589254,0.00001745805,0.0005792177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05530169,"threshold_uncertainty_score":0.4914569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015630644760426,"score_gpt":0.2719783547974114,"score_spread":0.2618220483498072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}