{"id":"W7116732864","doi":"10.2139/ssrn.5937835","title":"Adaptive versus Fixed Designs in Confirmatory Clinical Trials: Centering the Choice on Ethics","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Adaptive design; Matching (statistics); Research design; Process (computing); Engineering design process; Clinical study design; Construct (python library); Adaptation (eye)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4491842,0.002830238,0.007178679,0.002960687,0.001743611,0.006409862,0.004824561,0.01024333,0.01124623],"category_scores_gemma":[0.7227903,0.002263852,0.003576266,0.003332493,0.01863409,0.01453047,0.005433497,0.01579643,0.001043492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004109344,"about_ca_system_score_gemma":0.007078305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009791538,"about_ca_topic_score_gemma":0.001249557,"domain_scores_codex":[0.3385811,0.6323869,0.007921905,0.01114216,0.008681555,0.001286497],"domain_scores_gemma":[0.1078549,0.8462529,0.01346612,0.02655268,0.004478197,0.001395196],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00288713,0.0001738307,0.001548954,0.001479053,0.001097332,0.0001261872,0.001236091,0.006616129,0.0003211719,0.8947837,0.004798662,0.08493169],"study_design_scores_gemma":[0.001164549,0.000334639,0.0004740262,0.0004849593,0.000199428,0.00005996858,0.00009044352,0.01451637,0.0002668837,0.980079,0.002276654,0.0000531285],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.00980546,0.005327954,0.9552521,0.02167029,0.001117938,0.001012939,0.0001803596,0.000162308,0.005470718],"genre_scores_gemma":[0.2988265,0.003136921,0.6821603,0.007153816,0.002113556,0.004614719,0.0001200367,0.0002114055,0.001662831],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.5508158,"threshold_uncertainty_score":0.679254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8886305187440243,"score_gpt":0.6777312076702561,"score_spread":0.2108993110737682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}