{"id":"W7116748815","doi":"10.1111/his.70075","title":"<scp> <i>GREB1</i> </scp> ‐rearranged uterine tumour shares a common <scp>DNA</scp> methylation signature with <scp> <i>ESR1</i> </scp> ‐rearranged <scp>UTROSCT</scp>","year":2025,"lang":"en","type":"article","venue":"Histopathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University of Calgary; University of Alberta","funders":"","keywords":"Immunohistochemistry; Methylation; DNA methylation; Signature (topology); Uterus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001155091,0.001425163,0.001639217,0.0005550422,0.0007635527,0.0002060897,0.001354652,0.00166695,0.00002075344],"category_scores_gemma":[0.001952816,0.001386764,0.0006328369,0.001006654,0.0007170169,0.00006966054,0.0006253624,0.001477317,0.0001156553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003172253,"about_ca_system_score_gemma":0.0006004923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000175932,"about_ca_topic_score_gemma":0.0004744607,"domain_scores_codex":[0.9927002,0.0008895024,0.001334011,0.0023742,0.0008028231,0.001899279],"domain_scores_gemma":[0.9951308,0.0008342573,0.0009082553,0.001934708,0.0006704012,0.0005215159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003689864,0.0003800689,0.003851829,0.0003980823,0.0001506918,0.0002365501,0.001304326,0.0006852837,0.8441387,0.0001520792,0.1475727,0.001092787],"study_design_scores_gemma":[0.004600573,0.001336773,0.01426583,0.0003242671,0.0004697669,0.0005245286,0.001205042,0.0007021399,0.3032062,0.0006022325,0.6725461,0.0002165621],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450688,0.01960815,0.005531657,0.0002557764,0.001575315,0.001266042,0.0005800183,0.0004694283,0.02564479],"genre_scores_gemma":[0.9490862,0.001651504,0.003253893,0.00394679,0.001256991,0.0005307546,0.002291148,0.0003576681,0.03762503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5409324,"threshold_uncertainty_score":0.9998499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007777783398795549,"score_gpt":0.2484708457284111,"score_spread":0.2406930623296155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}