{"id":"W7116791432","doi":"10.1158/1535-7163.mct-25-0667","title":"Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Fonds de Recherche du Québec - Santé; American Cancer Society; Canadian Institutes of Health Research; Melanoma Research Alliance; National Heart, Lung, and Blood Institute; American Skin Association; Dermatology Foundation","keywords":"Mevalonate pathway; Programmed cell death; Simvastatin; GPX4; Cancer cell; Statin; Cancer; Apoptosis; In vivo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001639677,0.0003933181,0.0004059319,0.000135351,0.0001414863,0.0000736853,0.0002754225,0.0001992166,0.00002553859],"category_scores_gemma":[0.00001710159,0.0004034795,0.000164981,0.0003852144,0.00007821585,0.000004716666,0.0002761491,0.0001783657,0.000007345689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009865761,"about_ca_system_score_gemma":0.000326507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007895597,"about_ca_topic_score_gemma":0.0007203541,"domain_scores_codex":[0.9979685,0.00008231642,0.0003882935,0.000749297,0.0002313911,0.0005802084],"domain_scores_gemma":[0.9987963,0.00000819243,0.0000900229,0.0006684753,0.0002010467,0.0002359632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002001195,0.00004597024,0.0001157501,0.00005235873,0.0003645154,8.63777e-7,0.0004188103,0.0007018493,0.9573169,0.00002580324,0.000820142,0.03993691],"study_design_scores_gemma":[0.0005372771,0.0001025307,0.0006589387,0.00005852339,0.0001430551,0.000002162083,0.00005147839,0.00005990783,0.5911017,0.00003785605,0.4069502,0.0002963765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620445,0.02027483,0.006493807,0.005892619,0.003839383,0.0009945065,0.0001861254,0.00004452104,0.0002297037],"genre_scores_gemma":[0.9640533,0.008860619,0.00335443,0.01727154,0.002789416,0.0005935896,0.00004181909,0.0001412997,0.002893989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4061301,"threshold_uncertainty_score":0.9998417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133550122615228,"score_gpt":0.2773822437731999,"score_spread":0.2660467425470476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}