{"id":"W7116791432","doi":"10.1158/1535-7163.mct-25-0667","title":"Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Fonds de Recherche du Québec - Santé; American Cancer Society; Canadian Institutes of Health Research; Melanoma Research Alliance; National Heart, Lung, and Blood Institute; American Skin Association; Dermatology Foundation","keywords":"Mevalonate pathway; Programmed cell death; Simvastatin; GPX4; Cancer cell; Statin; Cancer; Apoptosis; In vivo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133526,0.0002300013,0.0002986251,0.0001592729,0.0001261603,0.0002192605,0.000137338,0.0001875559,0.001350792],"category_scores_gemma":[0.00007538769,0.00009221804,0.0002237795,0.0001164903,0.0001529545,0.0001581365,0.0001762186,0.0004450631,0.0002609852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284295,"about_ca_system_score_gemma":0.0002118801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004746456,"about_ca_topic_score_gemma":0.001437473,"domain_scores_codex":[0.9999062,0.00001913608,0.00001001534,0.00001353889,0.00002358283,0.00002755861],"domain_scores_gemma":[0.9999545,0.000007787885,0.00001171634,0.000008651536,0.000007428247,0.00001000112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651399,0.00004244302,0.0001968765,0.00004174932,0.000009800149,0.00001964185,0.0000129759,0.00009521871,0.9970334,0.00008921704,0.00006367893,0.002230012],"study_design_scores_gemma":[0.00004825087,0.000836686,0.001951124,0.000005329835,0.00001951009,0.0001514346,0.00002505448,0.0006575236,0.9927961,0.00005686796,0.003449084,0.000002964735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921784,0.002509864,0.003454427,0.0002643024,0.0000382114,0.00008650731,0.0002544255,0.00007879201,0.001135046],"genre_scores_gemma":[0.9934511,0.001458474,0.002330394,0.0000884262,0.00001025592,0.00004869245,0.0002877962,0.00001361984,0.002311111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350792,"threshold_uncertainty_score":0.004518867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133550122615228,"score_gpt":0.2773822437731999,"score_spread":0.2660467425470476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}