{"id":"W7116839488","doi":"10.1002/alz70861_108386","title":"MINDFuL: a Multi‐center, Randomized, Double‐blind, Placebo‐controlled Phase 2 Clinical Trial of XPro1595 for Patients with Early Alzheimer's Disease and Biomarkers of Inflammation","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cégep de Saint-Laurent; Toronto Public Health","funders":"","keywords":"Clinical trial; Biomarker; Disease; Inflammation; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001845868,0.002637153,0.002629894,0.0007124504,0.0006082164,0.00114385,0.001417161,0.002659588,0.01030234],"category_scores_gemma":[0.001389179,0.0008526142,0.001309682,0.0004155799,0.001284158,0.001535487,0.0006665679,0.002426327,0.001278374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006360391,"about_ca_system_score_gemma":0.001377232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005413275,"about_ca_topic_score_gemma":0.001856631,"domain_scores_codex":[0.9994839,0.0002267086,0.00002978657,0.0001237991,0.00004337088,0.00009232463],"domain_scores_gemma":[0.9993563,0.0001010772,0.0001723381,0.00004691179,0.00006020974,0.0002630915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9680491,0.01386616,0.0003772956,0.0006035585,0.0005233994,0.00004028131,0.00005207625,0.0002289621,0.003761759,0.000157022,0.001213062,0.01112737],"study_design_scores_gemma":[0.96358,0.03493958,0.0005517454,0.00001604591,0.0001188134,0.00001667054,0.00000876832,0.0001355955,0.0001818354,0.00009956016,0.0003429932,0.00000844329],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623667,0.003564788,0.001977964,0.001288784,0.0007612136,0.02196916,0.003234541,0.0005247515,0.004312044],"genre_scores_gemma":[0.9449432,0.002412746,0.006244847,0.003913542,0.0007234156,0.03095512,0.003077847,0.00006710728,0.0076622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01030234,"threshold_uncertainty_score":0.03446472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04603215370186076,"score_gpt":0.3752369854777337,"score_spread":0.3292048317758729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}