{"id":"W7116848401","doi":"10.1002/alz70855_096281","title":"Interrogating conserved transcriptomic signatures of cognitive resilience in the frontal cortex","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Transcriptome; Cognition; Frontal cortex; Resilience (materials science); Psychological resilience; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004335036,0.0002872487,0.0004106537,0.0008009238,0.0002557366,0.0004403377,0.0001869795,0.0002434788,0.001234167],"category_scores_gemma":[0.0006008475,0.0001014373,0.0004572259,0.0006656208,0.0003021297,0.0001697994,0.0004441089,0.0003081062,0.0003288945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003127437,"about_ca_system_score_gemma":0.0003539663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001903973,"about_ca_topic_score_gemma":0.003530616,"domain_scores_codex":[0.9997453,0.00002002528,0.00001302315,0.0001403775,0.00003837764,0.00004290499],"domain_scores_gemma":[0.9996802,0.0001092238,0.00009924236,0.00004245254,0.00003994487,0.00002902888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001034461,0.00009882644,0.2541754,0.000741826,0.0004980678,0.0003268697,0.0003610221,0.003347012,0.6867178,0.0009165435,0.00237961,0.04940262],"study_design_scores_gemma":[0.00004301545,0.0002820841,0.9288638,0.0001094074,0.0004352502,0.0008120021,0.00033606,0.006241787,0.04745976,0.002663561,0.01270979,0.00004351329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517753,0.001481684,0.0096766,0.0001405895,0.000013702,0.00002720421,0.0355657,0.0001847904,0.001134337],"genre_scores_gemma":[0.9532979,0.0007428586,0.007897187,0.0001785115,0.00001498738,0.0001289116,0.03707887,0.00007275208,0.0005879987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001903973,"threshold_uncertainty_score":0.004128695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015119640813009,"score_gpt":0.2620299320282869,"score_spread":0.2469102912152779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}