{"id":"W7116855806","doi":"10.64898/2025.12.19.695603","title":"From iPSCs to NPCs to cortical neurons: bioenergetic, neuronal, and calcium signaling phenotypes in bipolar disorder with and without familial mitochondrial disease","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression","keywords":"Mitochondrion; Induced pluripotent stem cell; Mitochondrial disease; Phenotype; mitochondrial fusion; Bioenergetics; DNAJA3; Mitochondrial DNA; Neurodegeneration","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102485,0.0001950144,0.0001893601,0.000230545,0.0001540115,0.0003360369,0.0001250699,0.0002395788,0.0008552607],"category_scores_gemma":[0.0001255644,0.0001061146,0.0001753221,0.0001637838,0.0001687364,0.00009155815,0.0001932373,0.0003154402,0.0002310401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339948,"about_ca_system_score_gemma":0.0001427086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303657,"about_ca_topic_score_gemma":0.002556294,"domain_scores_codex":[0.9999051,0.000007233236,0.00001593594,0.00002811445,0.00003029421,0.00001328851],"domain_scores_gemma":[0.9999522,0.000006739555,0.00001120246,0.000008629579,0.00001036408,0.00001087535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001760388,0.00003411613,0.002306185,0.00004566614,0.00001403165,0.0003374899,0.0000808302,0.00009108225,0.9931189,0.0001206424,0.0001043525,0.003570595],"study_design_scores_gemma":[0.00007209756,0.0004792298,0.1431102,0.0000634346,0.0001318967,0.004491849,0.0005278539,0.002859858,0.8413287,0.0005092883,0.006400484,0.00002521281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922317,0.0006088749,0.003669825,0.00005483004,0.00002886625,0.00004744353,0.001325433,0.00006894565,0.001964045],"genre_scores_gemma":[0.9940217,0.0005466696,0.00222481,0.00007558382,0.000004224239,0.00008588874,0.001640869,0.00002492019,0.00137532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303657,"threshold_uncertainty_score":0.002861142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009920533563066741,"score_gpt":0.2359484276514512,"score_spread":0.2260278940883844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}