{"id":"W7116855815","doi":"10.1002/mus.70120","title":"Phase 3b Extension Study <scp>MT</scp> ‐1186‐ <scp>A04</scp> to Evaluate the Continued Efficacy and Safety of Edaravone Oral Suspension for Up to an Additional 48 Weeks in Patients With Amyotrophic Lateral Sclerosis","year":2025,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Montreal Neurological Institute and Hospital","funders":"Cytokinetics; Biogen","keywords":"Edaravone; Amyotrophic lateral sclerosis; Suspension (topology); Dosing; Phases of clinical research; Multiple sclerosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002244462,0.001707536,0.001601403,0.0004642663,0.0006799472,0.00103395,0.0009475008,0.002011829,0.01398265],"category_scores_gemma":[0.001284088,0.0006384717,0.001894018,0.0003795604,0.00064014,0.0008508757,0.0003985623,0.00327609,0.002703428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009066305,"about_ca_system_score_gemma":0.002682048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001611282,"about_ca_topic_score_gemma":0.004335514,"domain_scores_codex":[0.9995546,0.0001781103,0.00002675537,0.00007722102,0.00006967819,0.00009352328],"domain_scores_gemma":[0.9988567,0.0001406499,0.000278574,0.00009933798,0.0002045065,0.0004202274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8441288,0.04541792,0.003820082,0.001214305,0.001637121,0.0001759688,0.000163574,0.0006701189,0.0347902,0.0003412417,0.01667447,0.05096618],"study_design_scores_gemma":[0.8516728,0.1338372,0.006563102,0.00006143688,0.0004334813,0.00018334,0.00002805913,0.0003549489,0.001847769,0.0001961437,0.004799398,0.00002226139],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478552,0.004925485,0.001657984,0.001623362,0.0006895374,0.02180953,0.0128568,0.0005413517,0.008040817],"genre_scores_gemma":[0.935949,0.003243508,0.006252937,0.004150417,0.0005633781,0.02334274,0.0147118,0.0001665514,0.01161976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01398265,"threshold_uncertainty_score":0.04677665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03860380429121957,"score_gpt":0.3268679658754064,"score_spread":0.2882641615841868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}