{"id":"W7116888737","doi":"10.1093/nar/gkaf1402","title":"HyperdCas12a-based multiplexed genetic regulation in <i>Candida albicans</i>","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"CRISPR; Genetic screen; Candida albicans; Gene; Human genetics; Functional genomics; Phenotype; Genome editing; Forward genetics; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002867026,0.0004870702,0.0003533604,0.0002946772,0.0002697442,0.0007028921,0.0006194141,0.0003799309,0.001205119],"category_scores_gemma":[0.0001996869,0.0002192674,0.0003327946,0.000258094,0.0003994295,0.0002102216,0.0004694832,0.0008281522,0.0004703498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007496322,"about_ca_system_score_gemma":0.0005844941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001795118,"about_ca_topic_score_gemma":0.003348846,"domain_scores_codex":[0.9995605,0.0000401274,0.00004905669,0.0001344181,0.0001643545,0.00005150824],"domain_scores_gemma":[0.9997942,0.00002737338,0.00006716859,0.00003912633,0.00002882715,0.00004332414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005400462,0.00002475119,0.0001004808,0.00002462276,0.000004943171,0.00003073451,0.000008878517,0.0002745507,0.9968997,0.0002325191,0.0000869061,0.002257878],"study_design_scores_gemma":[0.00000709938,0.00005779078,0.0004202386,0.000002625371,0.000004831306,0.00007077825,0.00000703148,0.001474905,0.9963038,0.0000461823,0.00159639,0.000008234255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9368754,0.00127348,0.04992421,0.0003903316,0.0001882322,0.0003243467,0.001993659,0.001921539,0.007108812],"genre_scores_gemma":[0.9567131,0.0005887472,0.03649069,0.0001525086,0.0000132615,0.0001898471,0.000777273,0.0002440197,0.004830545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795118,"threshold_uncertainty_score":0.005438983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721103123689934,"score_gpt":0.3590179739754146,"score_spread":0.3418069427385153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}