{"id":"W7116891756","doi":"10.1080/19490976.2025.2604867","title":"Microbes and medicines: interrelationships between pharmaceuticals and the gut microbiome","year":2025,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Microbiome; Gut flora; Gut microbiome; Drug; Human microbiome; Dysbiosis; Fecal bacteriotherapy; Drug development; Transcriptome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000479354,0.0002241233,0.0002947983,0.0001088077,0.0002888602,0.00006805856,0.0002101875,0.0001927345,0.0000208775],"category_scores_gemma":[0.00009468824,0.000159384,0.00006956474,0.0001461587,0.0007504137,0.000006058665,0.0003081848,0.0002164013,0.00001315023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001445086,"about_ca_system_score_gemma":0.00008081485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005698925,"about_ca_topic_score_gemma":0.00006579502,"domain_scores_codex":[0.9987122,0.0001639052,0.0003536032,0.000413035,0.00004312461,0.0003141448],"domain_scores_gemma":[0.9993566,0.0001222985,0.00007594846,0.0002930544,0.00006571996,0.00008641244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008173131,0.00002060483,0.01249531,0.0001141059,0.0001198653,7.726235e-7,0.0002464418,1.762849e-7,0.9604608,0.0004642526,0.02438211,0.00161384],"study_design_scores_gemma":[0.007999148,0.0001546574,0.07734731,0.0003826048,0.0004719127,0.0001573702,0.0009229732,0.00001991697,0.1881905,0.001375697,0.7223511,0.0006268827],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635015,0.02379517,0.0008633223,0.01005826,0.0002155127,0.0004993389,0.00006820559,0.00002350896,0.000975154],"genre_scores_gemma":[0.991044,0.002401423,0.0005273808,0.00337608,0.0001813287,0.00001579815,0.0001181904,0.00001806712,0.002317664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7722703,"threshold_uncertainty_score":0.6499493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024318086585677,"score_gpt":0.3088958591373172,"score_spread":0.2986526782714604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}