{"id":"W7116891756","doi":"10.1080/19490976.2025.2604867","title":"Microbes and medicines: interrelationships between pharmaceuticals and the gut microbiome","year":2025,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Microbiome; Gut flora; Gut microbiome; Drug; Human microbiome; Dysbiosis; Fecal bacteriotherapy; Drug development; Transcriptome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003711368,0.0003889809,0.0006387204,0.0008080925,0.0003189797,0.001785004,0.0001861476,0.0007563733,0.001909361],"category_scores_gemma":[0.0005499246,0.0001719094,0.0003128824,0.000870117,0.00055317,0.001089333,0.0008848429,0.0008509341,0.0003681189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004635104,"about_ca_system_score_gemma":0.0007497364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007757166,"about_ca_topic_score_gemma":0.0014449,"domain_scores_codex":[0.9996657,0.0001223277,0.00002658439,0.00005207493,0.0000938447,0.0000395437],"domain_scores_gemma":[0.9997624,0.0001191611,0.00005605804,0.000006541607,0.00003285905,0.0000230838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002721217,0.00008859243,0.004705304,0.01071755,0.0002843134,0.001159901,0.0006554697,0.0009907023,0.0594996,0.03016588,0.01267604,0.8787846],"study_design_scores_gemma":[0.00002084891,0.0006618957,0.02493551,0.004791818,0.0003388531,0.004168734,0.001345288,0.0008230362,0.01611029,0.02329178,0.9234252,0.00008670184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007688107,0.9829111,0.001838967,0.002792294,0.0004528277,0.00001070857,0.00005854292,0.00001891737,0.004228713],"genre_scores_gemma":[0.04233818,0.9500838,0.002930188,0.001164396,0.0005604272,0.00001722118,0.00005631137,0.000006291451,0.002843279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001909361,"threshold_uncertainty_score":0.006387472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024318086585677,"score_gpt":0.3088958591373172,"score_spread":0.2986526782714604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}