{"id":"W7116900343","doi":"10.64898/2025.12.20.695633","title":"Patient-Specific 3D Heart-On-a-Chip Model of Dilated Cardiomyopathy with Embedded Bead-Based Mapping of Tissue Contractility","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Dilated cardiomyopathy; Contractility; Heart failure; Chronotropic; Inotrope; Cardiomyopathy; Drug; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002133488,0.0004486662,0.0003051269,0.0001833624,0.000132939,0.0003749162,0.0005012263,0.000769389,0.001365406],"category_scores_gemma":[0.0001038561,0.0002430722,0.0003659017,0.0001081352,0.000207027,0.0001089934,0.000279282,0.0003150126,0.0002349149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523655,"about_ca_system_score_gemma":0.0003968032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001632504,"about_ca_topic_score_gemma":0.002048024,"domain_scores_codex":[0.9998894,0.00001279285,0.000005826484,0.00003079386,0.00003817577,0.00002305655],"domain_scores_gemma":[0.9999062,0.00002478536,0.00001602079,0.00001952209,0.00001436852,0.0000190988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001446282,0.000134323,0.001330457,0.0001736314,0.00006237729,0.0006758111,0.0000701118,0.04710659,0.9425116,0.0008446245,0.0009467713,0.00599904],"study_design_scores_gemma":[0.00008392608,0.0006081968,0.009579315,0.00002888097,0.0001055288,0.0005655445,0.00007990209,0.5050838,0.4754449,0.0004639108,0.007864206,0.0000917697],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8622028,0.001037802,0.1269865,0.0003253034,0.0001973428,0.0001274965,0.002178375,0.001278908,0.005665431],"genre_scores_gemma":[0.9451732,0.0005535575,0.04991755,0.0001350808,0.0000199345,0.0002273675,0.0008213768,0.00004838155,0.003103507],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001632504,"threshold_uncertainty_score":0.004567683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01530508284833731,"score_gpt":0.2339010641017196,"score_spread":0.2185959812533823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}